Klra4 anticorps (Killer Cell Lectin-Like Receptor, Subfamily A, Member 4) (FITC)

Details for Product anti-Klra4 Antibody No. ABIN2661975, Fournisseur: Connectez-vous pour afficher
Antigène
  • Chok
  • Klra32
  • Ly-49d
  • Ly49d
  • ly49r<129>
  • killer cell lectin-like receptor, subfamily A, member 4
  • Klra4
Reactivité
Souris
5
Hôte
Rat
5
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp Klra4 est conjugé à/à la FITC
2
1
Application
Flow Cytometry (FACS)
5
1
1
Options
Fournisseur
Connectez-vous pour afficher
N° du produit (Fournisseur)
Connectez-vous pour afficher
Clone 4E5
Isotype IgG2a kappa
Purification The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Plasmids, Primers & others Plasmids, Primers & others Klra4 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Ly49D (Klra4 Antibody Extrait)
Sujet Ly49D is a type II transmembrane protein belonging to the Ly49 family of NK-cell receptors in the C-type lectin superfamily. Ly49D is expressed on subsets of natural killer (NK) cells in C57BL/6, C3H/He and SJL mouse strains, but not Balb/c, DBA/2, AKR and CBA/J. The receptors form homodimers that bind to MHC class I alloantigens. Unlike inhibitory Ly49 family members, Ly49D lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) but contains a cytoplasmic immunoreceptor tyrosine-based activation motif. The activating receptor Ly49D delivers stimulatory signals for target cell lysis upon interacting with H2-Dd, Dr and Dsp2, but not with H2b or H2k class I antigens. Cross-linking of Ly49D activates intracellular kinase activity and calcium mobilization in NK cells. In 129/J mice, 4E5 antibody cross-reacts with Ly49O, LY49R and Ly49V.
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Protect from prolonged exposure to light. Do not freeze.
Stock 4 °C
Stockage commentaire The antibody solution should be stored undiluted between 2°C and 8°C.
Images (Fournisseur)
Flow Cytometry (FACS) image for anti-Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4) antibody (FITC) (ABIN2661975) anti-Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4) antibody (FITC)
Flow Cytometry (FACS) image for anti-Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4) antibody (FITC) (ABIN2661975) anti-Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4) antibody (FITC) (Image 2)
Background publications Gillory, Megison, Stewart, Mroczek-Musulman, Nabers, Waters, Kelly, Coleman, Markert, Gillespie, Friedman, Beierle: "Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma." dans: PLoS ONE, Vol. 8, Issue 10, pp. e77753, 2013 (PubMed).

Hanke, Takizawa, McMahon, Busch, Pamer, Miller, Altman, Liu, Cado, Lemonnier, Bjorkman, Raulet: "Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors." dans: Immunity, Vol. 11, Issue 1, pp. 67-77, 1999 (PubMed).

George, Mason, Ortaldo, Kumar, Bennett: "Positive recognition of MHC class I molecules by the Ly49D receptor of murine NK cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 4, pp. 2035-43, 1999 (PubMed).

Idris, Smith, Mason, Ortaldo, Scalzo, Yokoyama: "The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 11, pp. 6330-5, 1999 (PubMed).

Ortaldo, Mason, Winkler-Pickett, Raziuddin, Murphy, Mason: "Ly-49 receptor expression and functional analysis in multiple mouse strains." dans: Journal of leukocyte biology, Vol. 66, Issue 3, pp. 512-20, 1999 (PubMed).

Mason, Willette-Brown, Anderson, Gosselin, Shores, Love, Ortaldo, McVicar: "Characterization of an associated 16-kDa tyrosine phosphoprotein required for Ly-49D signal transduction." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 9, pp. 4148-52, 1998 (PubMed).

Ortaldo, Winkler-Pickett, Mason, Mason: "The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 3, pp. 1158-65, 1998 (PubMed).

Mason, Anderson, Yokoyama, Smith, Winkler-Pickett, Ortaldo: "The Ly-49D receptor activates murine natural killer cells." dans: The Journal of experimental medicine, Vol. 184, Issue 6, pp. 2119-28, 1997 (PubMed).

Takei, Brennan, Mager: "The Ly-49 family: genes, proteins and recognition of class I MHC." dans: Immunological reviews, Vol. 155, pp. 67-77, 1997 (PubMed).

Yokoyama, Seaman: "The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex." dans: Annual review of immunology, Vol. 11, pp. 613-35, 1993 (PubMed).

Avez-vous cherché autre chose?