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Klra4 anticorps (FITC)

Klra4 Reactivité: Souris FACS Hôte: Rat Monoclonal 4E5 FITC
N° du produit ABIN2661975
  • Antigène Tous les produits Klra4
    Klra4 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4))
    Reactivité
    Souris
    Hôte
    • 3
    Rat
    Clonalité
    • 3
    Monoclonal
    Conjugué
    • 1
    • 1
    • 1
    Cet anticorp Klra4 est conjugé à/à la FITC
    Application
    • 3
    • 1
    • 1
    Flow Cytometry (FACS)
    Purification
    The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
    Clone
    4E5
    Isotype
    IgG2a kappa
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Protect from prolonged exposure to light. Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Antigène
    Klra4 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4))
    Autre désignation
    Ly49D (Klra4 Produits)
    Synonymes
    anticorps Chok, anticorps Klra32, anticorps Ly-49d, anticorps Ly49d, anticorps ly49r<129>, anticorps killer cell lectin-like receptor, subfamily A, member 4, anticorps Klra4
    Sujet
    Ly49D is a type II transmembrane protein belonging to the Ly49 family of NK-cell receptors in the C-type lectin superfamily. Ly49D is expressed on subsets of natural killer (NK) cells in C57BL/6, C3H/He and SJL mouse strains, but not Balb/c, DBA/2, AKR and CBA/J. The receptors form homodimers that bind to MHC class I alloantigens. Unlike inhibitory Ly49 family members, Ly49D lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) but contains a cytoplasmic immunoreceptor tyrosine-based activation motif. The activating receptor Ly49D delivers stimulatory signals for target cell lysis upon interacting with H2-Dd, Dr and Dsp2, but not with H2b or H2k class I antigens. Cross-linking of Ly49D activates intracellular kinase activity and calcium mobilization in NK cells. In 129/J mice, 4E5 antibody cross-reacts with Ly49O, LY49R and Ly49V.
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