Klra4 anticorps (Killer Cell Lectin-Like Receptor, Subfamily A, Member 4) (FITC)

Details for Product anti-Klra4 Antibody No. ABIN2661975, Fournisseur: Connectez-vous pour afficher
  • Chok
  • Klra32
  • Ly-49d
  • Ly49d
  • ly49r<129>
  • killer cell lectin-like receptor, subfamily A, member 4
  • Klra4
Clonalité (Clone)
Monoclonal ()
Cet anticorp Klra4 est conjugé à/à la FITC
Flow Cytometry (FACS)
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N° du produit (Fournisseur)
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Clone 4E5
Isotype IgG2a kappa
Purification The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Plasmids, Primers & others Plasmids, Primers & others Klra4 products on genomics-online (e.g. as negative or positive controls)
Autre désignation Ly49D (Klra4 Antibody Extrait)
Sujet Ly49D is a type II transmembrane protein belonging to the Ly49 family of NK-cell receptors in the C-type lectin superfamily. Ly49D is expressed on subsets of natural killer (NK) cells in C57BL/6, C3H/He and SJL mouse strains, but not Balb/c, DBA/2, AKR and CBA/J. The receptors form homodimers that bind to MHC class I alloantigens. Unlike inhibitory Ly49 family members, Ly49D lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) but contains a cytoplasmic immunoreceptor tyrosine-based activation motif. The activating receptor Ly49D delivers stimulatory signals for target cell lysis upon interacting with H2-Dd, Dr and Dsp2, but not with H2b or H2k class I antigens. Cross-linking of Ly49D activates intracellular kinase activity and calcium mobilization in NK cells. In 129/J mice, 4E5 antibody cross-reacts with Ly49O, LY49R and Ly49V.
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Protect from prolonged exposure to light. Do not freeze.
Stock 4 °C
Stockage commentaire The antibody solution should be stored undiluted between 2°C and 8°C.
Images (Fournisseur)
Flow Cytometry (FACS) image for anti-Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4) antibody (FITC) (ABIN2661975) anti-Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4) antibody (FITC)
Flow Cytometry (FACS) image for anti-Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4) antibody (FITC) (ABIN2661975) anti-Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4) antibody (FITC) (Image 2)
Background publications Gillory, Megison, Stewart, Mroczek-Musulman, Nabers, Waters, Kelly, Coleman, Markert, Gillespie, Friedman, Beierle: "Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma." dans: PLoS ONE, Vol. 8, Issue 10, pp. e77753, 2013 (PubMed).

Hanke, Takizawa, McMahon, Busch, Pamer, Miller, Altman, Liu, Cado, Lemonnier, Bjorkman, Raulet: "Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors." dans: Immunity, Vol. 11, Issue 1, pp. 67-77, 1999 (PubMed).

George, Mason, Ortaldo, Kumar, Bennett: "Positive recognition of MHC class I molecules by the Ly49D receptor of murine NK cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 4, pp. 2035-43, 1999 (PubMed).

Idris, Smith, Mason, Ortaldo, Scalzo, Yokoyama: "The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 11, pp. 6330-5, 1999 (PubMed).

Ortaldo, Mason, Winkler-Pickett, Raziuddin, Murphy, Mason: "Ly-49 receptor expression and functional analysis in multiple mouse strains." dans: Journal of leukocyte biology, Vol. 66, Issue 3, pp. 512-20, 1999 (PubMed).

Mason, Willette-Brown, Anderson, Gosselin, Shores, Love, Ortaldo, McVicar: "Characterization of an associated 16-kDa tyrosine phosphoprotein required for Ly-49D signal transduction." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 9, pp. 4148-52, 1998 (PubMed).

Ortaldo, Winkler-Pickett, Mason, Mason: "The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 3, pp. 1158-65, 1998 (PubMed).

Mason, Anderson, Yokoyama, Smith, Winkler-Pickett, Ortaldo: "The Ly-49D receptor activates murine natural killer cells." dans: The Journal of experimental medicine, Vol. 184, Issue 6, pp. 2119-28, 1997 (PubMed).

Takei, Brennan, Mager: "The Ly-49 family: genes, proteins and recognition of class I MHC." dans: Immunological reviews, Vol. 155, pp. 67-77, 1997 (PubMed).

Yokoyama, Seaman: "The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex." dans: Annual review of immunology, Vol. 11, pp. 613-35, 1993 (PubMed).

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