Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) anticorps

Détails pour le produit réf. ABIN2665221, Fournisseur: Connectez-vous pour afficher
Antigène
  • CALM
  • CLTH
  • LAP
  • PAP180
  • fit-1
  • fit1
  • mKIAA4114
  • Calm
  • phosphatidylinositol binding clathrin assembly protein
  • PICALM
  • Picalm
Reactivité
Humain
72
49
33
4
4
4
4
4
3
2
2
2
1
Hôte
Souris
51
35
Clonalité (Clone)
Monoclonal ()
Conjugué
Inconjugué
8
6
6
4
4
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
41
28
15
15
13
12
8
7
6
4
3
3
2
2
Options
Fournisseur
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N° du produit (Fournisseur)
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Clone TW4-6H10
Isotype IgG1 kappa
Purification The antibody was purified by affinity chromatography.
Antigène
Autre désignation LAP (PICALM Antibody Extrait)
Sujet TGF-β1 (transforming growth factor β1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many types of cells. Platelets express high level of TGF-β. TGF-β is synthesized as a large protein precursor and then secreted as a complex of TGF-β and LAP (latency-associated peptide), in which LAP noncovalently associates with the dimeric mature TGF-β to prevent its activity. TGF-β requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-β binds to the integrins αvβ1, αvβ6, αvβ8, and α8β1 through RGD domain. TGF-β plays an important role in controlling proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-β is believed to be important in the regulation of the development of Treg, Th17, and Th9 cells. A study has shown that LAP is an activated Treg surface marker.
Pathways Synaptic Membrane
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire The antibody solution should be stored undiluted between 2°C and 8°C.
Images (Fournisseur)
ELISA image for anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) antibody (ABIN2665221) anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) antibody
Flow Cytometry (FACS) image for anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) antibody (ABIN2665221) anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) antibody (Image 2)
Flow Cytometry (FACS) image for anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) antibody (ABIN2665221) anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) antibody (Image 3)
Background publications Yi, Barnes, Hand, Polleux, Ehlers: "TGF-beta signaling specifies axons during brain development." dans: Cell, Vol. 142, Issue 1, pp. 144-57, 2010 (PubMed).

Tran, Andersson, Hardwick, Bebris, Illei, Shevach: "Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures." dans: Blood, Vol. 113, Issue 21, pp. 5125-33, 2009 (PubMed).

Lu, Munger, Steadele, Busald, Tellier, Schnapp: "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1." dans: Journal of cell science, Vol. 115, Issue Pt 23, pp. 4641-8, 2002 (PubMed).

Khalil: "TGF-beta: from latent to active." dans: Microbes and infection / Institut Pasteur, Vol. 1, Issue 15, pp. 1255-63, 2000 (PubMed).

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