BCL2 anticorps (B-Cell CLL/lymphoma 2)

Details for Product anti-BCL2 Antibody No. ABIN2666090, Fournisseur: Connectez-vous pour afficher
Antigène
  • Bcl-2
  • PPP1R50
  • bcl-2
  • AW986256
  • C430015F12Rik
  • D630044D05Rik
  • D830018M01Rik
  • BCL-2
  • Bcl2
  • BCL2, apoptosis regulator
  • B cell leukemia/lymphoma 2
  • B-cell CLL/lymphoma 2a
  • B-cell CLL/lymphoma 2 protein
  • BCL2
  • Bcl2
  • bcl2a
  • BCL-2
Reactivité
Humain, Souris, Rat (Rattus)
1235
264
253
70
38
21
19
19
6
4
3
3
3
2
2
Hôte
Lapin
655
644
19
6
2
Clonalité (Clone)
Polyclonal ()
Conjugué
Cet anticorp BCL2 est non-conjugé
61
55
48
46
36
23
22
21
18
11
11
11
11
10
10
10
10
10
10
10
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Flow Cytometry (FACS)
978
445
445
443
380
360
207
155
148
125
91
42
33
15
13
9
6
3
2
2
2
1
1
1
1
1
1
Options
Fournisseur
Connectez-vous pour afficher
N° du produit (Fournisseur)
Connectez-vous pour afficher
Clone Poly6119
Isotype IgG
Purification The antibody was purified by antigen-affinity chromatography.
Plasmids, Primers & others Plasmids, Primers & others BCL2 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Bcl-2 (BCL2 Antibody Extrait)
Sujet Bcl-2 (B-cell leukemia 2) is an apoptotic protein and a member of the Bcl-2 family containing BH1-4 domains. Two reported isoforms exist α=25 kD, β=22 kD. The Bcl-2 protein forms homo- or hetero-dimers with other Bcl-2 family members. Bcl-2 is distributed in the outer mitochondrial membrane, intracellular membrane nuclear envelope, and endoplasmic reticulum. This protein blocks apoptotic death by controlling mitochondrial membrane permeability. Cleavage of Bcl-2 can convert to pro-apoptotic (by cleavage of BH4 domain). Bcl-2 has been reported to regulate cell cycle progression via ROS. This protein is modified by ASK1/JNK1, PKC, ERKs, and stress-activated kinase phosphorylation and can be ubiquitinated. Bcl-2 has been shown to interact with Apaf-1, Raf-1, TP53BP2, caspase-3, and form heterodimers with Bax, Bad, Bak, Bcl-xL, and Bag-1. Bcl-2 is modified by phosphorylation and ubiquitination. The Poly6119 antibody has been shown to be useful for Western blotting of the human, mouse, and rat Bcl-2 protein.
Pathways Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Upon receipt, store between 2°C and 8°C.
Images (Fournisseur)
Immunofluorescence (IF) image for anti-B-Cell CLL/lymphoma 2 (BCL2) antibody (ABIN2666090) anti-B-Cell CLL/lymphoma 2 (BCL2) antibody
Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 2 (BCL2) antibody (ABIN2666090) anti-B-Cell CLL/lymphoma 2 (BCL2) antibody (Image 2)
Background publications Kim, Lee, Kim, Kwon, Jeong, Kim: "Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin J2." dans: Experimental & molecular medicine, Vol. 36, Issue 5, pp. 444-53, 2004 (PubMed).

Deng, Gao, May: "Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS." dans: Blood, Vol. 102, Issue 9, pp. 3179-85, 2003 (PubMed).

Huang: "Bcl-2 family proteins as targets for anticancer drug design." dans: Oncogene, Vol. 19, Issue 56, pp. 6627-31, 2001 (PubMed).

Yang, Zha, Jockel, Boise, Thompson, Korsmeyer: "Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death." dans: Cell, Vol. 80, Issue 2, pp. 285-91, 1995 (PubMed).

Tsujimoto, Croce: "Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 14, pp. 5214-8, 1986 (PubMed).

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