Histone Deacetylase 5 (HDAC5) (AA 572-587) anticorps

Détails pour le produit réf. ABIN2668266
Antigène
  • HD5
  • NY-CO-9
  • AI426555
  • Hdac4
  • mHDA1
  • mKIAA0600
  • ATHDA5
  • HDA5
  • MAF19.7
  • MAF19_7
  • histone deacetylase 5
  • histone deacetylase 5
  • HDAC5
  • Hdac5
  • HDA05
  • hdac5
Épitope
AA 572-587
46
22
11
10
10
5
4
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris
207
112
56
12
10
6
3
3
3
2
1
Hôte
Lapin
201
7
Clonalité
Polyclonal
Conjugué
Inconjugué
5
3
3
2
2
2
2
2
2
2
2
2
Application
Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
179
127
81
46
33
23
13
11
3
2
2
1
1
Options
Immunogène This HDAC5 antibody was raised against a synthetic peptide corresponding to amino acid residues 572-587 of human HDAC5.
Isotype IgG
Purification Affinity Purified
Antigène
Autre désignation HDAC5 (HDAC5 Antibody Extrait)
Sujet HDAC5 (Histone Deacetylase 5) is a member of the class IIa mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-ε-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the ε-amino group of a lysine residue. In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11). Like HDAC4, HDAC5 shuttles between the nucleus and cytoplasm. In muscle cells, this protein shuttles into the cytoplasm during myocyte differentiation. HDAC5 interacts with many different transcription factors including HDAC3, and may form multi- complex proteins.
Poids moléculaire 120 kDa
ID gène 10014
Pathways Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Monocarboxylic Acid Catabolic Process
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 μg/μL
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Stock -80 °C
Stockage commentaire Antibodies in solution can be stored at -80 °C for 2 years.
Date de péremption 6 months
Images (Fournisseur)
Western Blotting (WB) image for anti-Histone Deacetylase 5 (HDAC5) (AA 572-587) antibody (ABIN2668266) HDAC5 antibody tested by Western blot. Detection of HDAC5 by Western blot. NIH/3T3 ce...
Produit citée dans: Ow, Palanichamy Kala, Rao, Choi, Bharathy, Taneja: "G9a inhibits MEF2C activity to control sarcomere assembly." dans: Scientific reports, Vol. 6, pp. 34163, 2016 (PubMed).

Zhao, Yue, Zhu, Du: "AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5." dans: The Journal of biological chemistry, Vol. 286, Issue 18, pp. 16426-34, 2011 (PubMed).

Keedy, Archin, Gates, Espeseth, Hazuda, Margolis: "A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression." dans: Journal of virology, Vol. 83, Issue 10, pp. 4749-56, 2009 (PubMed).

Basile, Mantovani, Imbriano: "DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines." dans: The Journal of biological chemistry, Vol. 281, Issue 4, pp. 2347-57, 2006 (PubMed).

Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: "Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters." dans: Molecular and cellular biology, Vol. 25, Issue 9, pp. 3737-51, 2005 (PubMed).

Avez-vous cherché autre chose?