SMAD2 anticorps (SMAD, Mothers Against DPP Homolog 2) (pThr220)

Details for Product anti-SMAD2 Antibody No. ABIN2687787
Antigène
  • JV18
  • JV18-1
  • MADH2
  • MADR2
  • hMAD-2
  • hSMAD2
  • jv18
  • Xmad2
  • madh2
  • madr2
  • XSmad2
  • hmad-2
  • hsmad2
  • jv18-1
  • smad-2
  • fj43c06
  • wu:fj43c06
  • 7120426M23Rik
  • Madh2
  • Madr2
  • Smad-2
  • mMad2
  • MAD homolog 2
  • Mothers against DPP homolog 2
  • SMAD 2
  • Smad2
  • SMAD family member 2
  • SMAD family member 2-Z
  • SMAD family member 2 S homeolog
  • SMAD2
  • SMAD2Z
  • smad2
  • smad2.S
  • Smad2
Épitope
pThr220
61
59
37
29
20
18
15
13
12
11
11
11
7
6
5
5
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris
461
283
258
26
19
18
18
16
13
11
10
10
7
6
6
4
1
1
1
1
1
Hôte
Lapin
418
53
7
Clonalité
Polyclonal
Conjugué
Cet anticorp SMAD2 est non-conjugé
26
13
12
10
10
10
10
10
10
7
7
7
2
2
2
2
2
2
Application
Western Blotting (WB)
378
202
108
76
62
27
27
25
24
19
17
5
5
3
3
2
1
Options
Immunogène The antibody was produced against synthesized phosphopeptide derived from human Smad2 around the phosphorylation site of threonine 220 (P-E-TP-P-P).
Isotype IgG
Specificité Smad2 (Phospho-Thr220) Antibody detects endogenous levels of Smad2 only when phosphorylated at threonine 220.
Purification Affinity purified
Plasmids, Primers & others Plasmids, Primers & others SMAD2 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation SMAD2 (SMAD2 Antibody Extrait)
Sujet This gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ',mothers against decapentaplegic', (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Pathways Cycle Cellulaire, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
Indications d'application WB: 1:500~1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C,-20 °C
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