MAP2K3 anticorps (Mitogen-Activated Protein Kinase Kinase 3)

Details for Product anti-MAP2K3 Antibody No. ABIN2687990
Antigène
  • MAPKK3
  • MEK3
  • MKK3
  • PRKMK3
  • SAPKK-2
  • SAPKK2
  • AW212142
  • Prkmk3
  • mMKK3b
  • Mkk3
  • mitogen-activated protein kinase kinase 3
  • mitogen activated protein kinase kinase 3
  • MAP kinase activator XMEK3
  • MAP2K3
  • Map2k3
  • map2k3
Reactivité
Humain, Souris, Rat (Rattus)
341
183
153
56
39
6
5
5
4
3
1
1
1
1
Hôte
Lapin
255
86
Clonalité
Polyclonal
Conjugué
Cet anticorp MAP2K3 est non-conjugé
13
9
9
9
9
9
9
6
6
3
3
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
266
117
101
76
61
26
16
16
6
4
3
3
1
1
Options
Immunogène Synthetic peptide conjugated to KLH
Isotype IgG
Specificité Not yet tested in other species
Purification Affinity purified
Plasmids, Primers & others Plasmids, Primers & others MAP2K3 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation MEK3 (MAP2K3 Antibody Extrait)
Sujet This gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene
Pathways Signalisation MAPK, Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2
Indications d'application Peptide ELISA titer: 1:20,000-80,000 Western blot analysis: 1:200-1000 Immunohistochemistry: 1:200-400 Optimal dilutions/concentrations should be determined by the end use.
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer PBS, pH 7.4 with 0.02 % Sodium Azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C,-20 °C
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