Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX) anticorps (Biotin)

Détails pour le produit réf. ABIN2688921, Fournisseur: Connectez-vous pour afficher
Antigène
  • CD11C
  • SLEB6
  • RGD1561123
  • AI449405
  • Cd11c
  • Cr4
  • N418
  • integrin subunit alpha X
  • integrin alpha X
  • ITGAX
  • Itgax
Reactivité
Souris
514
160
30
19
16
12
10
2
2
2
2
2
1
1
1
1
Hôte
Hamster arménien
447
89
83
44
7
3
Clonalité (Clone)
Monoclonal ()
Conjugué
Biotin
55
55
49
37
22
18
17
13
13
12
10
9
9
8
8
8
7
7
7
6
6
6
6
5
5
5
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS)
513
189
157
122
95
85
83
73
60
13
13
9
6
5
5
5
3
2
2
2
1
1
1
1
1
1
Options
Fournisseur
Connectez-vous pour afficher
N° du produit (Fournisseur)
Connectez-vous pour afficher
Marque BD Pharmingen™
Immunogène C57BL/6 Mouse Intestinal Intraepithelial Lymphocytes
Clone HL3
Isotype IgG1, lambda
Attributs du produit The HL3 antibody reacts with the integrin αx chain of gp150, 95 (CD11c/CD18) which is expressed on dendritic cells and CD4- CD8+ intestinal intraepithelial lymphocytes (IEL) and is upregulated on IEL and lymph-node T cells following in vivo activation. CD11c is also found on human NK cells. Although its expression on mouse NK cells is not published, we have detected CD11c on mouse splenic NK cells. Cells of the monocyte/macrophage lineage have been reported to express low levels of CD11c. CD11c plays a role in binding of iC3b. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Expression of CD11c on spleen NK cells. C57BL/6 splenocytes were stained simultaneously with PE-conjugated anti-mouse NK-1.1 mAb PK136 (Cat. No. 557391/553165) and isotype control (left panel) or biotin-conjugated mAb HL3 (right panel), followed by Avidin-FITC (Cat. No. 554057). Flow cytometry was performed on a BD FACScan™ flow cytometry system.

BD Pharmingen™ Biotin Hamster Anti-Mouse CD11c - Biotin - Clone HL3 - Isotype Armenian Hamster IgG1, λ2 - Reactivity Ms - 0.5 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Antigène
Autre désignation CD11c (ITGAX Antibody Extrait)
Sujet Synonyms: Integrin αx chain
Pathways Activated T Cell Proliferation, Integrin Complex
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing protein stabilizer and ≤0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Stock 4 °C
Stockage commentaire Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Produit citée dans: Gao, Liu, Wen, Zhang, Durbin, Liu, Zheng: "Differentiation of monocytic cell clones into CD8 alpha+ dendritic cells (DC) suggests that monocytes can be direct precursors for both CD8 alpha+ and CD8 alpha- DC in the mouse." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 5927-35, 2003 (PubMed).

Pulendran, Lingappa, Kennedy, Smith, Teepe, Rudensky, Maliszewski, Maraskovsky: "Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 5, pp. 2222-31, 1997 (PubMed).

Maraskovsky, Brasel, Teepe, Roux, Lyman, Shortman, McKenna: "Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified." dans: The Journal of experimental medicine, Vol. 184, Issue 5, pp. 1953-62, 1996 (PubMed).

Huleatt, Lefrançois: "Antigen-driven induction of CD11c on intestinal intraepithelial lymphocytes and CD8+ T cells in vivo." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 11, pp. 5684-93, 1995 (PubMed).

Larson, Springer: "Structure and function of leukocyte integrins." dans: Immunological reviews, Vol. 114, pp. 181-217, 1990 (PubMed).

Avez-vous cherché autre chose?