IL1R2 anticorps (Interleukin 1 Receptor, Type II)

Details for Product anti-IL1R2 Antibody No. ABIN2688929
Antigène
Reactivité
Humain
138
33
25
2
Hôte
Souris
98
46
7
1
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp IL1R2 est non-conjugé
7
5
5
5
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), ELISA
90
81
22
17
15
13
11
9
7
7
5
4
2
1
1
1
1
1
1
Options
Marque BD Pharmingen™
Clone MNC2
Isotype IgG1, kappa
Attributs du produit CD121b, also known as interleukin-1 receptor type II (IL-1RII), has a significant role in the inflammatory response. Interleukin-1 receptor type II acts as a decoy receptor to regulate prolonged persistence of IL-1 by binding to IL-1 and preventing the formation of signaling complexes. Membrane IL-1 type II receptor forms a 60 kDa soluble IL-1 receptor type II upon proteolytic cleavage from various cell types after activation with secondary, IL-1 induced cytokines. The soluble IL-1 type II receptor consists of 398 amino acids and 29 amino acids within a short cytoplasmic domain. The MNC2 monoclonal antibody reacts with recombinant and native soluble human IL-1 receptor type II. Flow cytometric analysis for CD121b. Jurkat cells (Human T-cell leukemia, ATCC TIB-152) [Left Panel] or SR cells (Human lymphoblast, ATCC CRL-2262) [Right Panel] were stained either with a Mouse IgG1, κ isotype control (MN 555746) [dotted line] or with the Purified Mouse Anti-Human CD121b antibody (MN 552401) [solid line] in conjunction with a PE Goat Anti-Mouse Ig secondary antibody (MN 550589). Flow cytometry was performed on a BD FACSCalibur™ flow cytometry system.

BD Pharmingen™ Purified Mouse Anti-Human CD121B - Purified - Clone MNC2 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Antigène
Autre désignation CD121B (IL1R2 Antibody Extrait)
Sujet Synonyms: IL-1 Receptor Type II, IL-1 RII
Pathways Signalisation NF-kappaB
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store undiluted at 4°C.
Produit citée dans: Bessis, Guéry, Mantovani, Vecchi, Sims, Fradelizi, Boissier: "The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis." dans: European journal of immunology, Vol. 30, Issue 3, pp. 867-75, 2000 (PubMed).

Orlando, Sironi, Bianchi, Drummond, Boraschi, Yabes, Mantovani: "Role of metalloproteases in the release of the IL-1 type II decoy receptor." dans: The Journal of biological chemistry, Vol. 272, Issue 50, pp. 31764-9, 1998 (PubMed).