Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) anticorps (Biotin)

Détails pour le produit réf. ABIN2688958
Antigène
  • TNFRSF4
  • ACT35
  • CD134
  • Ly-70
  • Ox40
  • TXGP1L
  • Txgp1
  • OX40
  • TNF receptor superfamily member 4
  • tumor necrosis factor receptor superfamily, member 4
  • TNFRSF4
  • Tnfrsf4
Reactivité
Rat (Rattus)
129
99
57
10
4
4
2
2
2
Hôte
Souris
114
59
56
2
Clonalité (Clone)
Monoclonal ()
Conjugué
Biotin
32
18
17
5
4
4
3
3
3
3
3
3
2
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
110
104
68
31
18
17
13
13
8
4
3
2
2
2
2
2
2
1
1
Options
Marque BD Pharmingen™
Immunogène Activated rat lymph node cells
Clone OX
Isotype IgG2b, kappa
Attributs du produit The OX-40 antibody reacts with the 50- kDa OX-40 Antigen (CD134), also known as OX-40 Receptor, on CD4+ T lymphocytes activated in vitro and in vivo. The antigen is a member of the NGFR/TNFR superfamily, which includes low-affinity nerve growth factor receptor, TNF receptors, the Fas antigen, CD137 (4-1BB), CD27, CD30, and CD40. CD134 supplies costimulatory signals for T-cell proliferation and effector functions. While OX-40 mAb is not mitogenic, it does augment some in vitro T-cell responses. It is also reported to block binding of OX-40 Ligand to OX-40 Antigen.

BD Pharmingen™ Biotin Mouse Anti-Rat CD134 - Biotin - Clone OX-40 - Isotype Mouse IgG2b, κ - Reactivity Rat - 0.1 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Antigène
Autre désignation CD134 (TNFRSF4 Antibody Extrait)
Sujet Synonyms: OX-40 Antigen
Pathways Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Stock 4 °C
Stockage commentaire Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Produit citée dans: Weinberg, Vella, Croft: "OX-40: life beyond the effector T cell stage." dans: Seminars in immunology, Vol. 10, Issue 6, pp. 471-80, 1999 (PubMed).

al-Shamkhani, Birkeland, Puklavec, Brown, James, Barclay: "OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand." dans: European journal of immunology, Vol. 26, Issue 8, pp. 1695-9, 1996 (PubMed).

Smith, Farrah, Goodwin: "The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death." dans: Cell, Vol. 76, Issue 6, pp. 959-62, 1994 (PubMed).

Mallett, Fossum, Barclay: "Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor." dans: The EMBO journal, Vol. 9, Issue 4, pp. 1063-8, 1990 (PubMed).

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