TNFRSF4 anticorps (Biotin)

N° du produit ABIN2688958

Détail du produit anti-TNFRSF4 anticorps (Biotin)

Antigène: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNFRSF4 est conjugé à/à la Biotin

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: The OX-40 antibody reacts with the 50- kDa OX-40 Antigen (CD134), also known as OX-40 Receptor, on CD4+ T lymphocytes activated in vitro and in vivo. The antigen is a member of the NGFR/TNFR superfamily, which includes low-affinity nerve growth factor receptor, TNF receptors, the Fas antigen, CD137 (4-1BB), CD27, CD30, and CD40. CD134 supplies costimulatory signals for T-cell proliferation and effector functions. While OX-40 mAb is not mitogenic, it does augment some in vitro T-cell responses. It is also reported to block binding of OX-40 Ligand to OX-40 Antigen.

BD Pharmingen™ Biotin Mouse Anti-Rat CD134 - Biotin - Clone OX-40 - Isotype Mouse IgG2b, κ - Reactivity Rat - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Activated rat lymph node cells

Clone: OX

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-TNFRSF4 (Biotin) (ABIN2688958)

Weinberg, Vella, Croft: "OX-40: life beyond the effector T cell stage." dans: Seminars in immunology, Vol. 10, Issue 6, pp. 471-80, (1999) (PubMed).

al-Shamkhani, Birkeland, Puklavec, Brown, James, Barclay: "OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand." dans: European journal of immunology, Vol. 26, Issue 8, pp. 1695-9, (1996) (PubMed).

Smith, Farrah, Goodwin: "The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death." dans: Cell, Vol. 76, Issue 6, pp. 959-62, (1994) (PubMed).

Mallett, Fossum, Barclay: "Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor." dans: The EMBO journal, Vol. 9, Issue 4, pp. 1063-8, (1990) (PubMed).

Détails sur TNFRSF4

Antigène: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Autre désignation: CD134 (TNFRSF4 Produits)

Synonymes: anticorps TNFRSF4, anticorps ACT35, anticorps CD134, anticorps Ly-70, anticorps Ox40, anticorps TXGP1L, anticorps Txgp1, anticorps OX40, anticorps TNF receptor superfamily member 4, anticorps tumor necrosis factor receptor superfamily, member 4, anticorps TNFRSF4, anticorps Tnfrsf4

Sujet: Synonyms: OX-40 Antigen

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints