The OX-40 antibody reacts with the 50- kDa OX-40 Antigen (CD134), also known as OX-40 Receptor, on CD4+ T lymphocytes activated in vitro and in vivo. The antigen is a member of the NGFR/TNFR superfamily, which includes low-affinity nerve growth factor receptor, TNF receptors, the Fas antigen, CD137 (4-1BB), CD27, CD30, and CD40. CD134 supplies costimulatory signals for T-cell proliferation and effector functions. While OX-40 mAb is not mitogenic, it does augment some in vitro T-cell responses. It is also reported to block binding of OX-40 Ligand to OX-40 Antigen.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Stock
4 °C
Stockage commentaire
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Weinberg, Vella, Croft: "OX-40: life beyond the effector T cell stage." dans: Seminars in immunology, Vol. 10, Issue 6, pp. 471-80, (1999) (PubMed).
al-Shamkhani, Birkeland, Puklavec, Brown, James, Barclay: "OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand." dans: European journal of immunology, Vol. 26, Issue 8, pp. 1695-9, (1996) (PubMed).
Smith, Farrah, Goodwin: "The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death." dans: Cell, Vol. 76, Issue 6, pp. 959-62, (1994) (PubMed).
Mallett, Fossum, Barclay: "Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor." dans: The EMBO journal, Vol. 9, Issue 4, pp. 1063-8, (1990) (PubMed).
Antigène
TNFRSF4
(Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))