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PDGFRA anticorps

PDGFRA Reactivité: Humain FACS, IP, Func Hôte: Souris Monoclonal alphaR1 unconjugated
N° du produit ABIN2688972
  • Antigène Voir toutes PDGFRA Anticorps
    PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
    Reactivité
    • 247
    • 131
    • 71
    • 19
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 222
    • 40
    • 9
    • 1
    Souris
    Clonalité
    • 214
    • 58
    Monoclonal
    Conjugué
    • 116
    • 22
    • 19
    • 16
    • 15
    • 14
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    Cet anticorp PDGFRA est non-conjugé
    Application
    • 181
    • 114
    • 72
    • 54
    • 54
    • 46
    • 38
    • 24
    • 24
    • 15
    • 7
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
    Marque
    BD Pharmingen™
    Attributs du produit
    Reacts with platelet derived growth factor (PDGF) receptor α, CD140a, a 170 kD single transmembrane glycoprotein expressed on fibroblasts, smooth muscle cells, glial cells and chondrocytes. PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domain. They are structurally similar to M-CSF receptor and CD117 (c-kit). Their ligand, PDGF, is a mitogen for connective tissue cells and glial cells. PDGF plays a role in wound healing and it also acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils. Functional PDGF is secreted as a dimer, disulfide linked, A and B chains (PDGFAA, PDGF-BB or PDGF-AB). Binding of divalent PDGF induces receptor dimerization with three possible forms: αα, αβ, ββ. The PDGF receptor α-subunit binds both PDGF A and B chains, whereas the receptor β-subunit binds only PDGF B chains. Both receptor subunits can stimulate mitogenic responses, only the β subunit can induce chemotaxis. αR1 is specific for αPDGFR and does not cross react with βPDGFR. It immunoprecipitates human, monkey, rabbit, pig, dog and cat αPDGFR. It does not recognize hamster, rat or mouse αPDGFR. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of MG-63 (osteosarcoma cell line) cells analyzed by flow cytometry

    BD Pharmingen™ Purified Mouse Anti-Human CD140a - Purified - Clone αR1 (also known as Alpha-R1) - Isotype Mouse IgG2a, κ - Reactivity Hu - 0.1 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Clone
    AlphaR1
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product PDGFRA Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Bazenet, Kazlauskas: "The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP." dans: Oncogene, Vol. 9, Issue 2, pp. 517-25, (1994) (PubMed).

  • Antigène
    PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
    Autre désignation
    CD140a (PDGFRA Produits)
    Synonymes
    anticorps AI115593, anticorps CD140a, anticorps Pdgfr-2, anticorps APDGFR, anticorps PDGFACE, anticorps CD140A, anticorps PDGFR-2, anticorps PDGFR2, anticorps RHEPDGFRA, anticorps PDGFR, anticorps PDGFR-A, anticorps platelet derived growth factor receptor alpha, anticorps platelet derived growth factor receptor, alpha polypeptide, anticorps platelet-derived growth factor receptor, alpha polypeptide L homeolog, anticorps platelet-derived growth factor receptor, alpha polypeptide, anticorps PDGFRA, anticorps Pdgfra, anticorps pdgfra.L
    Sujet
    Synonyms: PDGF receptor α chain
    Pathways
    Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
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