PDGFRB anticorps (Platelet-Derived Growth Factor Receptor, beta Polypeptide)

Details for Product anti-PDGFRB Antibody No. ABIN2688973
Antigène
  • AI528809
  • CD140b
  • PDGFR-1
  • Pdgfr
  • CD140B
  • IBGC4
  • JTK12
  • PDGFR
  • PDGFR1
  • platelet derived growth factor receptor, beta polypeptide
  • platelet derived growth factor receptor beta
  • Pdgfrb
  • PDGFRB
Reactivité
Humain
511
286
247
9
8
8
8
6
2
2
2
1
1
1
Hôte
Souris
440
96
5
4
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp PDGFRB est non-conjugé
21
15
15
15
15
15
15
15
14
13
11
6
6
6
6
6
4
1
1
1
Application
Flow Cytometry (FACS)
306
146
135
83
79
58
57
23
14
12
7
3
2
2
2
1
Options
Marque BD Pharmingen™
Clone 28D4
Isotype IgG2a, kappa
Attributs du produit Reacts with platelet derived growth factor (PDGF) receptor β, a 170-190 kDa single transmembrane glycoprotein expressed on fibroblasts, smooth muscle cells, glial cells and chondrocytes. PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domains. They are structurally similar to M-CSF receptor and CD117 (c-kit). Their ligand, PDGF, is a mitogen for connective tissue cells and glial cells. PDGF plays a role in wound healing and acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils. Functional PDGF is secreted as a disulfide-linked dimer of A and B chains (PDGF-AA, PDGF-BB or PDGF-AB). Binding of divalent PDGF induces receptor dimerization with three possible forms: αα, αβ, ββ. The PDGF receptor α-subunit binds both PDGF A and B chains, whereas the receptor β-subunit binds only PDGF B chain. Both receptor subunits can stimulate mitogenic responses, only the β subunit can induce chemotaxis. 28D4 is specific for PDGFRβ and does not cross-react with PDGFRα. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of 697 cell line analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD140b - Purified - Clone 28D4 - Isotype Mouse IgG2a, κ - Reactivity Hu - 0.1 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Plasmids, Primers & others Plasmids, Primers & others PDGFRB products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation CD140b (PDGFRB Antibody Extrait)
Sujet Synonyms: PDGF Receptor β chain
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store undiluted at 4°C.
Produit citée dans: Ebert, Kasper, Hernberg, Friess, Büchler, Roessner, Korc, Malfertheiner: "Overexpression of platelet-derived growth factor (PDGF) B chain and type beta PDGF receptor in human chronic pancreatitis." dans: Digestive diseases and sciences, Vol. 43, Issue 3, pp. 567-74, 1998 (PubMed).

Yang, Khachigian, Hicks, Chesterman, Chong: "Identification of PDGF receptors on human megakaryocytes and megakaryocytic cell lines." dans: Thrombosis and haemostasis, Vol. 78, Issue 2, pp. 892-6, 1997 (PubMed).

Claesson-Welsh: "Platelet-derived growth factor receptor signals." dans: The Journal of biological chemistry, Vol. 269, Issue 51, pp. 32023-6, 1995 (PubMed).

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