TNFSF4 anticorps

N° du produit ABIN2689125

Détail du produit anti-TNFSF4 anticorps

Antigène: TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNFSF4 est non-conjugé

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: The ATM-2 antibody reacts with rat CD252 (OX-40 Ligand, OX-40L), a member of the TNF Ligand superfamily. Although there is controversy regarding mouse OX-40L expression, OX-40L has been shown to be expressed on human dendritic cells and mouse activated B lymphocytes. Rat OX-40L interacts with OX-40 Antigen (CD134) found predominantly on activated T cells. The OX-40L-OX-40 interaction is reciprocally costimulatory in that both T cells and B cells are activated in cross-linking. Rat OX-40L mRNA has been detected in various HTLV-I-transformed T-cell lines: F344-S1, WKA-S1, and ACI-S1. In addition, total rat spleen cells activated with 5 ng/mL PMA and 0.5 μg/mL ionomycin for two days showed OX-40L expression, as determined by flow cytometric analysis, with the ATM-2 mAb. As observed in the mouse and human systems, rat OX-40L also costimulates IL-2 production and proliferation of anti- D3-activated rat T cells. The ATM-2 mAb blocks the costimulatory activity of OX-40L on rat T- cell proliferation.

BD Pharmingen™ Purified Mouse Anti-Rat CD252 - Purified - Clone ATM-2 - Isotype Mouse IgG1, κ - Reactivity Rat - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: ACI-S1 rat T-cell lymphoma cell line

Clone: ATM

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-TNFSF4 (ABIN2689125)

Ohshima, Tanaka, Tozawa, Takahashi, Maliszewski, Delespesse: "Expression and function of OX40 ligand on human dendritic cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 8, pp. 3838-48, (1997) (PubMed).

Calderhead, Buhlmann, van den Eertwegh, Claassen, Noelle, Fell: "Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 10, pp. 5261-71, (1993) (PubMed).

Paterson, Jefferies, Green, Brandon, Corthesy, Puklavec, Williams: "Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts." dans: Molecular immunology, Vol. 24, Issue 12, pp. 1281-90, (1988) (PubMed).

Détails sur TNFSF4

Antigène: TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))

Autre désignation: CD252 (TNFSF4 Produits)

Synonymes: anticorps TNFSF4, anticorps OX40L, anticorps TNFRSF4, anticorps CD134L, anticorps CD252, anticorps GP34, anticorps OX-40L, anticorps OX4OL, anticorps TXGP1, anticorps Ath-1, anticorps Ath1, anticorps Ox40l, anticorps Txgp1l, anticorps gp34, anticorps TNF superfamily member 4, anticorps tumor necrosis factor (ligand) superfamily, member 4, anticorps TNFSF4, anticorps Tnfsf4

Sujet: Synonyms: OX-40L, OX-40 Ligand

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation, Cancer Immune Checkpoints