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ICOS anticorps

ICOS Reactivité: Humain FACS Hôte: Souris Monoclonal DX29 unconjugated
N° du produit ABIN2689138
  • Antigène Voir toutes ICOS Anticorps
    ICOS (Inducible T-Cell Co-Stimulator (ICOS))
    Reactivité
    • 96
    • 36
    • 32
    • 6
    Humain
    Hôte
    • 76
    • 17
    • 13
    • 2
    • 1
    Souris
    Clonalité
    • 73
    • 36
    Monoclonal
    Conjugué
    • 40
    • 14
    • 9
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ICOS est non-conjugé
    Application
    • 65
    • 35
    • 34
    • 34
    • 14
    • 13
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Marque
    BD Pharmingen™
    Attributs du produit
    Monoclonal antibody DX29 reacts with inducible costimulatory (ICOS) molecule. ICOS is a homodimeric membrane glycoprotein, member of the CD28 family, of approximately 50 - 60 kDa, highly expressed on activated T cells. It is the receptor for B7 related protein 1 (B7RP-1) and also, like CD28, ICOS is costimulatory signal for T cell activation, proliferation and cytokine production. It is not expressed on resting or activated B cells, monocytes, NK cells, granulocytes, dendritic cells or platelets. Unlike the constitutively expressed CD28, ICOS expression is de novo. Reports describe similarities of CD28 and ICOS in T cell activation, however, it has been suggested that ICOS may play an important role in IL-10 production. In presence IL-10, purified recombinant human ICOS significantly increased in vitro B cell growth stimulated by pokeweed mitogen (PWM) and enhanced production of IgG. Profile of ICOS (DX29) reactivity on PHA-stimulated peripheral blood mononuclear cells analyzed by flow cytometry. Second step staining with Cat. No. 555988.

    BD Pharmingen™ Purified Mouse Anti-Human CD278 - Purified - Clone DX29 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Activated human T cells
    Clone
    DX29
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product ICOS Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Dong, Nurieva: "Regulation of immune and autoimmune responses by ICOS." dans: Journal of autoimmunity, Vol. 21, Issue 3, pp. 255-60, (2003) (PubMed).

    Okamoto, Tezuka, Kato, Abe, Tsuji: "PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production." dans: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 691-702, (2003) (PubMed).

    Sakamoto, Tezuka, Tsuji, Hori, Tamatani: "AILIM/ICOS: its expression and functional analysis with monoclonal antibodies." dans: Hybridoma and hybridomics, Vol. 20, Issue 5-6, pp. 293-303, (2002) (PubMed).

    Aicher, Hayden-Ledbetter, Brady, Pezzutto, Richter, Magaletti, Buckwalter, Ledbetter, Clark: "Characterization of human inducible costimulator ligand expression and function." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 9, pp. 4689-96, (2000) (PubMed).

  • Antigène
    ICOS (Inducible T-Cell Co-Stimulator (ICOS))
    Autre désignation
    CD278 (ICOS Produits)
    Synonymes
    anticorps ICOS, anticorps AILIM, anticorps CCLP, anticorps CRP-1, anticorps H4, anticorps Ly115, anticorps CD278, anticorps CVID1, anticorps Ailim, anticorps inducible T-cell costimulator, anticorps inducible T cell co-stimulator, anticorps inducible T-cell co-stimulator, anticorps ICOS, anticorps LOC100232284, anticorps Icos
    Sujet
    Synonyms: ICOS
    Pathways
    Cancer Immune Checkpoints
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