Reacts with a 120 kD type I transmembrane glycoprotein expressed on in-vitro stimulated T and B cells. CD30 is an activation marker which was initially identified on Reed-Sternberg cells and is also expressed on a few extrafollicular T and B cells located at the rim of germinal centers. It is a cytokine receptor which belongs to the nerve growth factor receptor/tumor necrosis factor receptor (NGFR/TNFR) superfamily. CD30 interaction with CD30 ligand (CD30L) can mediate signals for proliferation, apoptosis and cytotoxicity of lymphoid cells. Profile of YT (NK cell line) cells analyzed on a FACScan
BD Pharmingen™ Biotin Mouse Anti-Human CD30 - Biotin - Clone BerH8 (also known as Ber-H8) - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg
Purification
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Stock
4 °C
Stockage commentaire
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Guesdon, Ternynck, Avrameas: "The use of avidin-biotin interaction in immunoenzymatic techniques." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 27, Issue 8, pp. 1131-9, (1979) (PubMed).
Antigène
TNFRSF8
(Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))