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CD4 anticorps

CD4 Reactivité: Souris FACS, IP, IHC (fro), BR, IHC (f), IHC (zinc) Hôte: Rat Monoclonal H129-19 unconjugated
N° du produit ABIN2689225
  • Antigène Voir toutes CD4 Anticorps
    CD4
    Reactivité
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    • 120
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    Rat
    Clonalité
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    Monoclonal
    Conjugué
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    Cet anticorp CD4 est non-conjugé
    Application
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Zinc-fixed Sections) (IHC (zinc))
    Marque
    BD Pharmingen™
    Attributs du produit
    The H129.19 antibody reacts with the CD4 (L3T4) differentiation antigen expressed on thymocytes, a subpopulation of mature T lymphocytes (i.e., MHC class II-restricted T cells, including most T helper cells), and a subset of NK-T cells of all mouse strains tested. CD4 has also been detected on pluirpotent hematopoietic stem cells, bone marrow myeloid precursors, intrathymic lymphoid precursors, and a subset of splenic dendritic cells. CD4 is expressed on the plasma membrane of mouse egg cells and is involved in adhesion of the egg to MHC class II-bearing sperm. CD4 is an antigen coreceptor on the T-cell surface which interacts with MHC class II molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine lck. H129.19 mAb blocks binding of the anti-mouse CD4 mAbs Gk1.5 (Cat. No. 557307/553729) and RM4-5 (Cat. No. 553046/553047), but not RM4-4 (Cat. No. 553055) antibody. mAb H129.19 inhibits various responses of T helper cells to antigenic or mitogenic stimuli. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

    BD Pharmingen™ Purified Rat Anti-Mouse CD4 - Purified - Clone H129.19 - Isotype Rat IgG2a, κ - Reactivity Ms - 0.5 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    A.TH mouse CTL clone A15.1.17
    Clone
    H129-19
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product CD4 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Martín, del Hoyo, Anjuère, Ruiz, Arias, Marín, Ardavín: "Concept of lymphoid versus myeloid dendritic cell lineages revisited: both CD8alpha(-) and CD8alpha(+) dendritic cells are generated from CD4(low) lymphoid-committed precursors." dans: Blood, Vol. 96, Issue 7, pp. 2511-9, (2000) (PubMed).

    Bendelac: "Mouse NK1+ T cells." dans: Current opinion in immunology, Vol. 7, Issue 3, pp. 367-74, (1995) (PubMed).

    Guo, Watanabe, Mori, Mori: "Molecular structure and function of CD4 on murine egg plasma membrane." dans: Zygote (Cambridge, England), Vol. 3, Issue 1, pp. 65-73, (1995) (PubMed).

    Godfrey, Kennedy, Mombaerts, Tonegawa, Zlotnik: "Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 10, pp. 4783-92, (1994) (PubMed).

    Janeway: "The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation." dans: Annual review of immunology, Vol. 10, pp. 645-74, (1992) (PubMed).

    Wineman, Gilmore, Gritzmacher, Torbett, Müller-Sieburg: "CD4 is expressed on murine pluripotent hematopoietic stem cells." dans: Blood, Vol. 80, Issue 7, pp. 1717-24, (1992) (PubMed).

    Wu, Antica, Johnson, Scollay, Shortman: "Developmental potential of the earliest precursor cells from the adult mouse thymus." dans: The Journal of experimental medicine, Vol. 174, Issue 6, pp. 1617-27, (1992) (PubMed).

    Wu, Scollay, Egerton, Pearse, Spangrude, Shortman: "CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus." dans: Nature, Vol. 349, Issue 6304, pp. 71-4, (1991) (PubMed).

    Bierer, Sleckman, Ratnofsky, Burakoff: "The biologic roles of CD2, CD4, and CD8 in T-cell activation." dans: Annual review of immunology, Vol. 7, pp. 579-99, (1989) (PubMed).

    Frederickson, Basch: "L3T4 antigen expression by hemopoietic precursor cells." dans: The Journal of experimental medicine, Vol. 169, Issue 4, pp. 1473-8, (1989) (PubMed).

    Ghobrial, Boublik, Winn, Auchincloss: "In vivo use of monoclonal antibodies against murine T cell antigens." dans: Clinical immunology and immunopathology, Vol. 52, Issue 3, pp. 486-506, (1989) (PubMed).

    Regnier-Vigouroux, Blanc, Pont, Marchetto, Pierres: "Accessory molecules and T cell activation. I. Antigen receptor avidity differentially influences T cell sensitivity to inhibition by monoclonal antibodies to LFA-1 and L3T4." dans: European journal of immunology, Vol. 16, Issue 11, pp. 1385-90, (1987) (PubMed).

    Pont, Régnier-Vigouroux, Marchetto, Pierres: "Accessory molecules and T cell activation. II. Antibody binding to L3T4a inhibits Ia-independent mouse T cell proliferation." dans: European journal of immunology, Vol. 17, Issue 3, pp. 429-32, (1987) (PubMed).

    Naquet, Malissen, Bekkhoucha, Pont, Pierres, Hood, Pierres: "L3T4 but not LFA-1 participates in antigen presentation by Ak-positive L-cell transformants." dans: Immunogenetics, Vol. 22, Issue 3, pp. 247-56, (1985) (PubMed).

    Pierres, Naquet, Van Agthoven, Bekkhoucha, Denizot, Mishal, Schmitt-Verhulst, Pierres et al.: "A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among ..." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 132, Issue 6, pp. 2775-82, (1984) (PubMed).

  • Antigène
    CD4
    Autre désignation
    CD4 (CD4 Produits)
    Synonymes
    anticorps cd4, anticorps L3T4, anticorps Ly-4, anticorps CD4mut, anticorps W3/25, anticorps p55, anticorps CD4 molecule, anticorps carcinoembryonic antigen-related cell adhesion molecule 5, anticorps T-cell surface glycoprotein CD4, anticorps CD4 antigen, anticorps Cd4 molecule, anticorps CD4, anticorps LOC100125525, anticorps cd4, anticorps Cd4
    Sujet
    Synonyms: L3T4
    Pathways
    TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events
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