Immunoglobulin (Ig) antigen receptors are composed of a non-covalently-associated complex of Ig and two other proteins, Igα and Igβ, clustered as CD79a and CD79b, respectively. CD79b is a membrane glycoprotein of 229 residues, with a predicted relative molecular mass of 36-40 kDa. Its expression is restricted to B lineage cells, has been reported to associate with surface IgM receptor, and may be involved in signal transduction. Antibody 3A2-2E7 (also known as SN8) was generated by immunization of cell membrane preparations from B-prolymphocytic leukemia cells. It has similar reactivity characteristics as clone CB3-1 (another CD79b available from BD Biosciences Pharmingen, Cat. No. 555678). Antibodies CD3-1 and 3A2-2E7 reacts with an epitope that is enhanced on certain B-cell leukemias such as prolymphocytic leukemia and lymphoma, but not on chronic lymphocytic leukemia. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of human CD79b expression on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.
BD Pharmingen™ Purified Mouse Anti-Human CD79b - Purified - Clone 3A2-2E7 (also known as SN8) - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
Purification
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store undiluted at 4°C.
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