CD56 anticorps

N° du produit ABIN2689855

Détail du produit anti-CD56 anticorps

Antigène: CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD56 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Marque: BD Pharmingen™

Attributs du produit: The R19-760 monoclonal antibody specifically binds to NCAM-1 (Neural cell adhesion molecule 1) that is also known as CD56 and NKH1. NCAM-1 is a heavily glycosylated transmembrane protein and a member of the Ig supergene family. NCAM-1 represents an isoform of the neural cell adhesion molecule (NCAM). In the hematopoietic system, it is present on approximately 10 % to 25 % of peripheral blood lymphocytes. It is expressed on natural killer (NK) cells and a subset of T cells, NKT cells. It is not expressed on myeloid cells, erythrocytes or B cells. This molecule appears to function as an adhesion molecule and can serve as a panspecific NK-cell marker. The R19-760 antibody recognizes an epitope in the NCAM-1 (CD56) extracellular domain that resists destruction due to cellular fixation with BD Phosflow™ Lyse/Fix Buffer and permeabilization with BD Phosflow™ Perm Buffer III. Analyses of NCAM-1 (CD56) expression by Immunohistochemistry and

BD Pharmingen™ Purified Mouse Anti-Human NCAM-1 (CD56) - Purified - Clone R19-760 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human NCAM1 Recombinant Protein

Clone: R19

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-CD56 (ABIN2689855)

Gerosa, Baldani-Guerra, Nisii, Marchesini, Carra, Trinchieri: "Reciprocal activating interaction between natural killer cells and dendritic cells." dans: The Journal of experimental medicine, Vol. 195, Issue 3, pp. 327-33, (2002) (PubMed).

Galandrini, Tassi, Mattia, Lenti, Piccoli, Frati, Santoni: "SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells." dans: Blood, Vol. 100, Issue 13, pp. 4581-9, (2002) (PubMed).

Cooper, Fehniger, Caligiuri: "The biology of human natural killer-cell subsets." dans: Trends in immunology, Vol. 22, Issue 11, pp. 633-40, (2001) (PubMed).

Bennett, Zatsepina, Zamai, Azzoni, Mikheeva, Perussia: "Definition of a natural killer NKR-P1A+/CD56-/CD16- functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12." dans: The Journal of experimental medicine, Vol. 184, Issue 5, pp. 1845-56, (1996) (PubMed).

Lanier, Chang, Azuma, Ruitenberg, Hemperly, Phillips: "Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56)." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 12, pp. 4421-6, (1991) (PubMed).

Nitta, Yagita, Sato, Okumura: "Involvement of CD56 (NKH-1/Leu-19 antigen) as an adhesion molecule in natural killer-target cell interaction." dans: The Journal of experimental medicine, Vol. 170, Issue 5, pp. 1757-61, (1989) (PubMed).

Lanier, Testi, Bindl, Phillips: "Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule." dans: The Journal of experimental medicine, Vol. 169, Issue 6, pp. 2233-8, (1989) (PubMed).

Schubert, Zimmermann, Cramer, Starzinski-Powitz: "Lymphocyte antigen Leu-19 as a molecular marker of regeneration in human skeletal muscle." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 1, pp. 307-11, (1989) (PubMed).

Cunningham, Hemperly, Murray, Prediger, Brackenbury, Edelman: "Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing." dans: Science (New York, N.Y.), Vol. 236, Issue 4803, pp. 799-806, (1987) (PubMed).

Edelman: "Cell adhesion molecules in the regulation of animal form and tissue pattern." dans: Annual review of cell biology, Vol. 2, pp. 81-116, (1987) (PubMed).

Phillips, Lanier: "Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis." dans: The Journal of experimental medicine, Vol. 164, Issue 3, pp. 814-25, (1986) (PubMed).

Lanier, Le, Civin, Loken, Phillips: "The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 136, Issue 12, pp. 4480-6, (1986) (PubMed).

Détails sur CD56

Antigène: CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))

Autre désignation: NCAM-1 CD56 (NCAM1 Produits)

Synonymes: anticorps CD56, anticorps MSK39, anticorps NCAM, anticorps fj56g09, anticorps ncam, anticorps ncam1, anticorps wu:fj56g09, anticorps NCAM1, anticorps n-cam, anticorps E-NCAM, anticorps NCAM-1, anticorps Ncam, anticorps Cd56, anticorps N-CAM, anticorps N-CAM-1, anticorps NCAM-C, anticorps NCAMC, anticorps N-CAM-1-B, anticorps NCAM-1-B, anticorps ncam1-a, anticorps ncam1-b, anticorps neural cell adhesion molecule 1, anticorps neural cell adhesion molecule 1a, anticorps neural cell adhesion molecule 1 S homeolog, anticorps neural cell adhesion molecule 1 L homeolog, anticorps NCAM1, anticorps ncam1a, anticorps ncam1, anticorps LOC100085373, anticorps ncam1.S, anticorps Ncam1, anticorps ncam1.L

Sujet: Synonyms: N-CAM-1, Neural cell adhesion molecule 1, NKH1, MSK39, Leu-19