Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.
Subcellular location: Cytoplasm, Nucleus
Synonyms: GRF-1, GRLF1, P190A, P190-A, p190RhoGAP, p190ARhoGAP, Rho GTPase-activating protein 35, Glucocorticoid receptor DNA-binding factor 1, Glucocorticoid receptor repression factor 1, Rho GAP p190A, ARHGAP35, GRF1, KIAA1722