PTPN13 anticorps (AA 2290-2491)

N° du produit ABIN2712101

Détail du produit anti-PTPN13 anticorps

Antigène: PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))

Épitope: AA 2290-2491

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPN13 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody reacts to Fas-associated Protein Tyrosine Phosphatase 1 (FAP-1) (PTPN13).

Purification: Immunoaffinity Chromatography

Immunogène: PTPN13 antibody was raised against recombinant protein encoding aa 2290-2491 of human FAP-1 Genename: PTPN13

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: 10 mM PBS, pH 7.4, BSA, sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PTPN13

Antigène: PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))

Autre désignation: PTPN13 (PTPN13 Produits)

Synonymes: anticorps FAP-1, anticorps PNP1, anticorps PTP-BAS, anticorps PTP-BL, anticorps PTP1E, anticorps PTPL1, anticorps PTPLE, anticorps hPTP1E, anticorps PTPN13, anticorps AI324989, anticorps Ptpri, anticorps RIP, anticorps Ptp-bl, anticorps ptp, anticorps wu:fb50g04, anticorps zgc:162319, anticorps protein tyrosine phosphatase, non-receptor type 13, anticorps tyrosine-protein phosphatase non-receptor type 13, anticorps PTPN13, anticorps LOC100540743, anticorps ptpn13, anticorps Ptpn13

Sujet: Fas-associated phosphatase-1 (FAP-1), a NT7 non-receptor protein tyrosine phosphatase, is comprised of a N-terminal FERM domain, five PDZ domains, and a C-terminal tyrosine phosphatase domain. The protein has been shown to bind the cytosolic tail of Fas (Apo1, CD95) and regulate Fas-induced apoptosis. Human tumor cell lines become resistant to Fas-mediated apoptosis when transfected with FAP-1, indicating that FAP-1 functions as a negative regulator in Fas-mediated death signaling. FAS resistance has been documented in a variety of cancers, including cancer of the lung, ovary, pancreas, and liver. At least three protein isoforms of FAP-1 have been reported. Alterations in FAP-1 expression have been shown to result in defects in cytokinesis.Synonyms: FAP1, Fas-associated protein-tyrosine phosphatase 1, PNP1, PTP-BAS, PTP-E1, PTP1E, PTPL1, Protein-tyrosine phosphatase 1E, Protein-tyrosine phosphatase PTPL1, Tyrosine-protein phosphatase non-receptor type 13

ID gène: 5783

NCBI Accession: NP_006255

UniProt: Q12923