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Osteoprotegerin anticorps

TNFRSF11B Reactivité: Humain, Souris, Rat WB, IF, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN272130
  • Antigène Voir toutes Osteoprotegerin (TNFRSF11B) Anticorps
    Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
    Reactivité
    • 60
    • 20
    • 17
    • 2
    • 2
    • 2
    • 2
    Humain, Souris, Rat
    Hôte
    • 49
    • 12
    • 2
    • 1
    Lapin
    Clonalité
    • 53
    • 11
    Polyclonal
    Conjugué
    • 42
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Osteoprotegerin est non-conjugé
    Application
    • 48
    • 29
    • 26
    • 17
    • 11
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects endogenous levels of Osteoprotegerin protein.
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography using epitope-specific immunogen
    Top Product
    Discover our top product TNFRSF11B Anticorps primaire
  • Indications d'application
    ELISA: 1/5000approx. 1/10000. Western blot 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 15 mM Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
    Autre désignation
    Osteoprotegerin / TNFRSF11B (TNFRSF11B Produits)
    Synonymes
    anticorps CD254, anticorps ODF, anticorps OPGL, anticorps OPTB2, anticorps RANKL, anticorps TRANCE, anticorps hRANKL2, anticorps sOdf, anticorps OCIF, anticorps OPG, anticorps TR1, anticorps Opg, anticorps ocif, anticorps opg, anticorps tr1, anticorps TNF superfamily member 11, anticorps TNF receptor superfamily member 11b, anticorps tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin), anticorps TNF receptor superfamily member 11B, anticorps tumor necrosis factor receptor superfamily member 11b S homeolog, anticorps tumor necrosis factor receptor superfamily, member 11b, anticorps TNFSF11, anticorps TNFRSF11B, anticorps Tnfrsf11b, anticorps tnfrsf11b.S
    Classe de substances
    Chemical
    Sujet
    Bone morphogenesis and remodeling involve the formation of bone from osteoblasts and the resorption of bone by osteoclasts. The cytokine osteoprotegerin (OPG), also designated Osteoclastogenesis Inhibitory Factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFα and TNFβ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.Synonyms: OCIF, OPG, Osteoclastogenesis inhibitory factor, Tumor necrosis factor receptor superfamily member 11B
    Poids moléculaire
    approx. 46 kDa
    ID gène
    4982
    NCBI Accession
    NP_002537
    UniProt
    O00300
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