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CSTF1 anticorps

CSTF1 Reactivité: Humain, Souris, Rat WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN272214
  • Antigène Voir toutes CSTF1 Anticorps
    CSTF1 (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 1, 50kDa (CSTF1))
    Reactivité
    • 27
    • 17
    • 16
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 25
    • 2
    Lapin
    Clonalité
    • 25
    • 2
    Polyclonal
    Conjugué
    • 20
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CSTF1 est non-conjugé
    Application
    • 17
    • 8
    • 8
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects endogenous levels of CstF-50 protein (region surrounding Arg3)
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Pureté
    > 95 % pure by SDS-PAGE
    Top Product
    Discover our top product CSTF1 Anticorps primaire
  • Indications d'application
    ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    DO NOT FREEZE!
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    CSTF1 (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 1, 50kDa (CSTF1))
    Autre désignation
    CSTF1 (CSTF1 Produits)
    Synonymes
    anticorps fc22d10, anticorps zgc:66207, anticorps zgc:77560, anticorps wu:fc22d10, anticorps wu:fd16h09, anticorps MGC53063, anticorps MGC69421, anticorps MGC83790, anticorps 1700057K18Rik, anticorps AI788832, anticorps CstF-50, anticorps CstFp50, anticorps cleavage stimulation factor, 3' pre-RNA, subunit 1, anticorps cleavage stimulation factor subunit 1, anticorps cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa, anticorps cstf1, anticorps cstf1.S, anticorps CSTF1, anticorps cstf1.L, anticorps Cstf1
    Sujet
    Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits of 77, 64 and 50 kDa. Heterotrimeric CstF recognizes GU and U-rich sequences located downstream of the polyadenylation site on RNA. The 50 kDa CstF subunit shares extensive homology with mammalian G protein beta-subunits and has a transducin repeat domain, which is a 44 amino acid-long sequence that is repeated seven times. CstF-50 interacts with the nuclear protein BARD1 (BRCA1-associated RING domain protein) and inhibits polyadenylation in vitro. CstF-50 may also be responsible for the interaction of the heterotrimeric CstF complex with other polyadenylation and 3'-end cleavage factors to form a stable complex on the pre-mRNA.Synonyms: CF-1 50 kDa subunit, CSTF 50 kDa subunit, Cleavage stimulation factor 50 kDa subunit, CstF-50, CstFp50
    Poids moléculaire
    approx. 48 kDa
    ID gène
    1477
    NCBI Accession
    NP_001028693
    UniProt
    Q05048
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