ERAP1 anticorps

N° du produit ABIN272255

Détail du produit anti-ERAP1 anticorps

Antigène: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERAP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of ERAP1 protein. (region surrounding Lys467)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/20000approx. 1/40000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry (Paraffin): 1/50-1/200. Immunofluorescence: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ERAP1

Antigène: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Autre désignation: ERAP1 / ARTS1 (ERAP1 Produits)

Synonymes: anticorps MGC166160, anticorps DKFZp469C044, anticorps ARTS-1, anticorps A-LAP, anticorps ALAP, anticorps APPILS, anticorps ARTS1, anticorps ERAAP, anticorps ERAAP1, anticorps PILS-AP, anticorps PILSAP, anticorps Arts1, anticorps PILSA, anticorps Appils, anticorps endoplasmic reticulum aminopeptidase 1, anticorps endoplasmic reticulum aminopeptidase 1b, anticorps ERAP1, anticorps erap1, anticorps erap1b, anticorps Erap1

Sujet: The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is a 120 kDa protein localized to the lumen of the ER, which removes NH2-terminal residues from many antigenic precursors for MHC class I peptide presentation. Peptides that are presented by MHC class I on the surface of a cell must be 8-11 residues long, and ERAP1 specifically trims peptides of 9 amino acids or more. ERAP1 is also induced by interferon-γ. The gene encoding human ERAP1 maps to chromosome 5q15. ERAP1 has previously been characterized as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1). A-LAP is thought to inactivate several bioactive peptides, including angiotensin II and, subsequently, may be involved in the regulation of blood pressure. PILS-AP is described as playing a role in angiogenesis by regulating the proliferation and migration of endothelial cells, and ARTS-1 is characterized as a TNFR1 binding protein that promotes TNFR1 shedding. Further research will be necessary to fully elucidate the functions of this protein.Synonyms: APPILS, ARTS-1, Adipocyte-derived leucine aminopeptidase, Aminopeptidase PILS, Endoplasmic reticulum aminopeptidase 1, KIAA0525, Puromycin-insensitive leucyl-specific aminopeptidase, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

Poids moléculaire: approx. 110 kDa

ID gène: 51752

NCBI Accession: NP_001035548

UniProt: Q9NZ08