CABLES1 anticorps

N° du produit ABIN272292

Détail du produit anti-CABLES1 anticorps

Antigène: CABLES1 (Cdk5 and Abl Enzyme Substrate 1 (CABLES1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CABLES1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Cables1 protein. (region surrounding Lys588)

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur CABLES1

Antigène: CABLES1 (Cdk5 and Abl Enzyme Substrate 1 (CABLES1))

Autre désignation: CABLES1 (CABLES1 Produits)

Synonymes: anticorps CABLES1, anticorps si:dkey-2p18.3, anticorps CABL1, anticorps CABLES, anticorps HsT2563, anticorps IK3-1, anticorps Cables, anticorps ik3-1, anticorps Cdk5 and Abl enzyme substrate 1, anticorps CDK5 and Abl enzyme substrate 1, anticorps CABLES1, anticorps cables1, anticorps CpipJ_CPIJ019832, anticorps Cables1

Sujet: Normal Abl function is essential for humans because Philadelphia chromosome translocation involving the ABL gene causes chronic myelogenous leukemia. Abl associates with a broad range of targets and appears to function in various signaling pathways. Cables, a 568 amino-acid protein, links Abl to cyclin-dependent kinase 5 (Cdk5). Cables bound to Cdk5 functions as a substrate for phosphorylation by the Cdk5/p35 kinase. Cables contains an area of weak homology to cyclin A and cyclin C. In addition to its C-terminal Cdk5 binding domain, Cables also has six potential SH3 binding motifs (PXXP) clustered around the amino terminus, two of which are similar to motifs known to bind the Abl SH3 domain. Cables forms a trimolecular complexwith Cdk5 and Abl in vivo. All three proteins colocalize within cortical axons, particularly in their growth cones. Cables and Abl may function as adaptor or scaffolding proteins to bind to Cdk5 and control its subcellular location in the neuron.Synonyms: CDK5 and ABL1 enzyme substrate 1, Ik3-1, Interactor with CDK3 1

Poids moléculaire: approx. 67 kDa

ID gène: 91768

NCBI Accession: NP_001094089

UniProt: Q8TDN4