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PTPRJ anticorps (AA 1-444) (Biotin)

PTPRJ Reactivité: Humain FACS Hôte: Souris Monoclonal MEM-CD148-05 Biotin
N° du produit ABIN2749044
  • Antigène Voir toutes PTPRJ Anticorps
    PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))
    Épitope
    • 12
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-444
    Reactivité
    • 47
    • 17
    • 13
    • 1
    • 1
    Humain
    Hôte
    • 31
    • 20
    Souris
    Clonalité
    • 31
    • 19
    Monoclonal
    Conjugué
    • 24
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PTPRJ est conjugé à/à la Biotin
    Application
    • 36
    • 17
    • 16
    • 13
    • 10
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody MEM-CD148/05 recognizes an extracellular epitope of CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosin phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
    Immunogène
    Human recombinant CD148 (amino acids 1-444)
    Clone
    MEM-CD148-05
    Isotype
    IgG2b
    Top Product
    Discover our top product PTPRJ Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-12 μg/mL.
    Commentaires

    The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Antigène
    PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))
    Autre désignation
    CD148 (PTPRJ Produits)
    Synonymes
    anticorps HAAP, anticorps CD148, anticorps DEP1, anticorps HPTPeta, anticorps R-PTP-ETA, anticorps SCC1, anticorps AI450271, anticorps BET, anticorps Byp, anticorps DEP-1, anticorps PTPbeta2, anticorps Ptpb2, anticorps RPTPJ, anticorps Scc-1, anticorps Scc1, anticorps PTPRJ, anticorps acid phosphatase 1, anticorps protein tyrosine phosphatase, receptor type J, anticorps protein tyrosine phosphatase, receptor type, J, anticorps ACP1, anticorps PTPRJ, anticorps Ptprj, anticorps EUBREC_2762
    Sujet
    Protein tyrosine phosphatase receptor type J,CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase, containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.,HPTP-eta, DEP-1, PTPRJ, DEP1, SCC1, HPTPeta, R-PTP-ETA
    ID gène
    5795
    UniProt
    Q12913
    Pathways
    EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
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