ARHGEF4 anticorps (AA 143-271) (PE)

N° du produit ABIN2749098

Détail du produit anti-ARHGEF4 anticorps (PE)

Antigène: ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))

Épitope: AA 143-271

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ARHGEF4 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: The mouse monoclonal antibody ARHGEF-08 recognizes human intracellular protein ARHGEF4 / ASEF1, approx. 80 kDa guanine nucleotide exchange factor specific for Rac1 and Cdc42. The epitope is located in the rough at the region of SH3 domain.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Recombinant fragment of human ARHGEF4 (amino acids 143-271)

Clone: ARHGEF-08

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-5 μg/mL. Intracellular staining.

Commentaires:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate was purified by size-exclusion chromatography.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Détails sur ARHGEF4

Antigène: ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))

Autre désignation: ARHGEF4 (ARHGEF4 Produits)

Synonymes: anticorps ARHGEF4, anticorps ASEF, anticorps ASEF1, anticorps GEF4, anticorps STM6, anticorps 9330140K16Rik, anticorps Asef, anticorps ENSMUSG00000070955, anticorps Rho guanine nucleotide exchange factor 4, anticorps uncharacterized LOC100470646, anticorps rho guanine nucleotide exchange factor 4, anticorps Rho guanine nucleotide exchange factor (GEF) 4, anticorps ARHGEF4, anticorps arhg4, anticorps LOC100470646, anticorps LOC100544917, anticorps Arhgef4

Sujet: Rho guanine nucleotide exchange factor 4,ARHGEF4 (Rho guanine nucleotide exchange factor 4), also known as ASEF 1 (adenomatous polyposis coli –, stimulated guanine nucleotide exchange factor 1) is an approximately 80 kDa cytoplasmic protein important for growth factor-mediated regulation of cell morphology and migration. Besides N-terminal adenomatous polyposis coli (APC)-binding region (ABR) it contains Dbl homology (DH), pleckstrin homology (PH) and SH3 domains. The SH3 domain inhibits GEF activity of ARHGEF4 by intramolecular interaction with the DH domain, whereas binding of APC stimulates the GEF activity. Activated ARHGEF4 stimulates the small GTPase Cdc42, which leads to decreased cell-cell adherence and enhanced cell migration.,ASEF1, GEF4, STM6

ID gène: 50649

UniProt: Q9NR80

Pathways: Neurotrophin Signaling Pathway