PTPRJ anticorps (AA 1-444) (APC)

N° du produit ABIN2749107

Détail du produit anti-PTPRJ anticorps (APC)

Antigène: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Épitope: AA 1-444

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PTPRJ est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Specificité: The mouse monoclonal antibody MEM-CD148/05 recognizes an extracellular epitope of CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosin phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Human recombinant CD148 (amino acids 1-444)

Clone: MEM-CD148-05

Isotype: IgG2b

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Commentaires:

The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Restrictions: For Research Use only

Stockage

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Détails sur PTPRJ

Antigène: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Autre désignation: CD148 (PTPRJ Produits)

Synonymes: anticorps HAAP, anticorps CD148, anticorps DEP1, anticorps HPTPeta, anticorps R-PTP-ETA, anticorps SCC1, anticorps AI450271, anticorps BET, anticorps Byp, anticorps DEP-1, anticorps PTPbeta2, anticorps Ptpb2, anticorps RPTPJ, anticorps Scc-1, anticorps Scc1, anticorps PTPRJ, anticorps acid phosphatase 1, anticorps protein tyrosine phosphatase, receptor type J, anticorps protein tyrosine phosphatase, receptor type, J, anticorps ACP1, anticorps PTPRJ, anticorps Ptprj, anticorps EUBREC_2762

Sujet: Protein tyrosine phosphatase receptor type J,CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase, containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.,HPTP-eta, DEP-1, PTPRJ, DEP1, SCC1, HPTPeta, R-PTP-ETA

ID gène: 5795

UniProt: Q12913

Pathways: EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling