DR3/LARD anticorps (PE)

N° du produit ABIN2749186

Détail du produit anti-DR3/LARD anticorps (PE)

Antigène: DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DR3/LARD est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: The mouse monoclonal antibody JD3 recognizes an extracellular epitope of DR3 (APO-3, TNFRSF25), a transmembrane protein of TNFR superfamily expressed mainly in lymphocyte-enriched tissues.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: human DR3-Ig fusion protein

Clone: JD3

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Commentaires:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Restrictions: For Research Use only

Stockage

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-DR3/LARD (PE) (ABIN2749186)

Cavallini, Lovato, Bertolaso, Pacelli, Zoratti, Zanolin, Krampera, Zamò, Tecchio, Cassatella, Pizzolo, Scupoli: "The TNF-family cytokine TL1A inhibits proliferation of human activated B cells." dans: PLoS ONE, Vol. 8, Issue 4, pp. e60136, (2013) (PubMed).

Jones, Stumhofer, Foster, Twohig, Hertzog, Topley, Williams, Hunter, Jenkins, Wang, Jones: "Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 1, pp. 409-19, (2011) (PubMed).

Yi, Zhang, Schwartz-Albiez, Cao: "Mechanisms of the apoptosis induced by CD176 antibody in human leukemic cells." dans: International journal of oncology, Vol. 38, Issue 6, pp. 1565-73, (2011) (PubMed).

Nakayama, Ishidoh, Kayagaki, Kojima, Yamaguchi, Nakano, Kominami, Okumura, Yagita: "Multiple pathways of TWEAK-induced cell death." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 2, pp. 734-43, (2002) (PubMed).

Détails sur DR3/LARD

Antigène: DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))

Autre désignation: DR3 / TRAMP (TNFRSF25 Produits)

Synonymes: anticorps APO-3, anticorps DDR3, anticorps DR3, anticorps LARD, anticorps TNFRSF12, anticorps TR3, anticorps TRAMP, anticorps WSL-1, anticorps WSL-LR, anticorps Tnfrsf12, anticorps Wsl, anticorps TNFRSF25, anticorps TNF receptor superfamily member 25, anticorps tumor necrosis factor receptor superfamily, member 25, anticorps TNFRSF25, anticorps Tnfrsf25

Sujet: TNF receptor superfamily member 25,DR3, also known as APO-3, TRAMP or TNFRSF25, is a death domain-containing receptor of TNFR family, which is expressed preferentially in peripheral blood leukocytes and in the lymphocyte-enriched tissues. Its expression has been shown to be especially up-regulated in activated T cells. DR3 participates e.g. in the removal of self-reactive T cells in the thymus. The ligand for DR3 is TL1A (TNF-like ligand 1A), which is expressed in a variety of cell types (induced by inflammatory stimuli), and can also be released as a soluble factor. The TL1A/DR3 axis has been shown to costimulate T cells to produce a wide variety of cytokines and leads to T cell differentiation towards Th1 and Th17 types.,TNFRSF25, TR3, DDR3, LARD, APO-3, TRAMP, WSL-1, WSL-LR, TNFRSF12

ID gène: 8718

UniProt: Q93038

Pathways: Apoptose