Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

FAS anticorps

FAS Reactivité: Humain FACS, Func Hôte: Souris Monoclonal EOS9-1 unconjugated
N° du produit ABIN2749190
  • Antigène Voir toutes FAS Anticorps
    FAS (TNF Receptor Superfamily, Member 6 (FAS))
    Reactivité
    • 226
    • 68
    • 66
    • 19
    • 9
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 159
    • 101
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Souris
    Clonalité
    • 156
    • 115
    • 1
    Monoclonal
    Conjugué
    • 130
    • 29
    • 25
    • 12
    • 11
    • 7
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FAS est non-conjugé
    Application
    • 167
    • 130
    • 75
    • 68
    • 40
    • 36
    • 34
    • 26
    • 26
    • 20
    • 19
    • 11
    • 8
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func)
    Specificité
    The mouse monoclonal antibody EOS9.1 recognizes an extracellular epitope of CD95 (Fas/APO-1), a 46 kDa glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells.
    Réactivité croisée (Details)
    Human
    Purification
    Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
    Pureté
    > 95 % (by SDS-PAGE)
    niveau d'endotoxine
    Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
    Immunogène
    P815 cells transfected with human CD95
    Clone
    EOS9-1
    Isotype
    IgM kappa
    Top Product
    Discover our top product FAS Anticorps primaire
  • Indications d'application
    Functional application: In vitro induction of apoptosis.
    Flow cytometry: Recommended dilution: 2-6 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4
    Agent conservateur
    Azide free
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Matsuoka, Kim, McDonough, Bascug, Warshauer, Koreth, Cutler, Ho, Alyea, Antin, Soiffer, Ritz: "Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation." dans: The Journal of clinical investigation, Vol. 120, Issue 5, pp. 1479-93, (2010) (PubMed).

    Kasper, Konze, Kern, Stippel: "CD95 and TNFα-induced apoptosis in liver metastases of colorectal carcinoma." dans: In vivo (Athens, Greece), Vol. 24, Issue 5, pp. 653-7, (2010) (PubMed).

    Conejo-Garcia, Benencia, Courreges, Gimotty, Khang, Buckanovich, Frauwirth, Zhang, Katsaros, Thompson, Levine, Coukos: "Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells." dans: Cancer research, Vol. 64, Issue 6, pp. 2175-82, (2004) (PubMed).

    Desbarats, Birge, Mimouni-Rongy, Weinstein, Palerme, Newell: "Fas engagement induces neurite growth through ERK activation and p35 upregulation." dans: Nature cell biology, Vol. 5, Issue 2, pp. 118-25, (2003) (PubMed).

  • Antigène
    FAS (TNF Receptor Superfamily, Member 6 (FAS))
    Autre désignation
    CD95 / Fas (FAS Produits)
    Synonymes
    anticorps ALPS1A, anticorps APO-1, anticorps APT1, anticorps CD95, anticorps FAS1, anticorps FASTM, anticorps TNFRSF6, anticorps AI196731, anticorps APO1, anticorps TNFR6, anticorps Tnfrsf6, anticorps lpr, anticorps Fas cell surface death receptor, anticorps Fas (TNF receptor superfamily member 6), anticorps FAS, anticorps Fas, anticorps fas
    Sujet
    Fas cell surface death receptor,CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.,FAS1, APT1, APO-1, FASTM, ALPS1A, TNFRSF6
    ID gène
    355
    UniProt
    P25445
    Pathways
    Signalisation p53, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
Support technique