The mouse monoclonal antibody UP-R1 recognizes an extracellular epitope on CD158f (KIR2DL5), a 60 kDa glycoprotein serving as a HLA class I ligand, and mainly expressed on a subset of NK cells and a small population of T cells. Its expression is highly polymorphic between individuals.
KIR2DL5A
Reactivité: Humain
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Flow cytometry: Recommended dilution: 1-4 μg/mL.
Restrictions
For Research Use only
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store at 2-8°C. Do not freeze.
Estefanía, Flores, Gómez-Lozano, Aguilar, López-Botet, Vilches: "Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 7, pp. 4402-10, (2007) (PubMed).
Antigène
KIR2DL5A
(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))
anticorps CD158F, anticorps KIR2DL5, anticorps KIR2DL5.1, anticorps KIR2DL5.3, anticorps KIR2DL5B, anticorps killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A, anticorps KIR2DL5A
Sujet
Killer cell immunoglobulin like receptor, two Ig d,CD158f, also known as KIR2DL5, is a polymorphic 60 kDa transmembrane glycoprotein with two Ig-like extracellular domains by which it recognize HLA class I molecules. Its long intracellular domain contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that upon extracellular ligand-mediated phosphorylation serve as docking sites for inhibitory phosphatases, which results in blocking natural cytotoxicity as well as antibody-dependent cytotoxicity of the particular NK cell, and its adhesion toward target cells. Together with other killer inhibitory receptors CD158f is important for immunological tolerance to discriminate between normal and abnormal cells. Besides NK cells it is expressed on a small population of cytotoxic T cells. Expression of CD158f alleles is highly variable in the population.,KIR2DL5A