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KIR2DL5A anticorps

KIR2DL5A Reactivité: Humain FACS, ICC Hôte: Souris Monoclonal UP-R1 unconjugated
N° du produit ABIN2749214
  • Antigène Voir toutes KIR2DL5A Anticorps
    KIR2DL5A (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))
    Reactivité
    • 27
    • 1
    • 1
    Humain
    Hôte
    • 21
    • 6
    Souris
    Clonalité
    • 22
    • 5
    Monoclonal
    Conjugué
    • 13
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp KIR2DL5A est non-conjugé
    Application
    • 9
    • 8
    • 4
    • 4
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Specificité
    The mouse monoclonal antibody UP-R1 recognizes an extracellular epitope on CD158f (KIR2DL5), a 60 kDa glycoprotein serving as a HLA class I ligand, and mainly expressed on a subset of NK cells and a small population of T cells. Its expression is highly polymorphic between individuals.
    Réactivité croisée (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Human CD158f-Ig fusion protein
    Clone
    UP-R1
    Isotype
    IgG1 kappa
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Estefanía, Flores, Gómez-Lozano, Aguilar, López-Botet, Vilches: "Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 7, pp. 4402-10, (2007) (PubMed).

  • Antigène
    KIR2DL5A (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))
    Autre désignation
    CD158f (KIR2DL5A Produits)
    Synonymes
    anticorps CD158F, anticorps KIR2DL5, anticorps KIR2DL5.1, anticorps KIR2DL5.3, anticorps KIR2DL5B, anticorps killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A, anticorps KIR2DL5A
    Sujet
    Killer cell immunoglobulin like receptor, two Ig d,CD158f, also known as KIR2DL5, is a polymorphic 60 kDa transmembrane glycoprotein with two Ig-like extracellular domains by which it recognize HLA class I molecules. Its long intracellular domain contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that upon extracellular ligand-mediated phosphorylation serve as docking sites for inhibitory phosphatases, which results in blocking natural cytotoxicity as well as antibody-dependent cytotoxicity of the particular NK cell, and its adhesion toward target cells. Together with other killer inhibitory receptors CD158f is important for immunological tolerance to discriminate between normal and abnormal cells. Besides NK cells it is expressed on a small population of cytotoxic T cells. Expression of CD158f alleles is highly variable in the population.,KIR2DL5A
    ID gène
    57292
    UniProt
    Q8N109
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