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PLA2R1 anticorps (AA 395-530)

PLA2R1 Reactivité: Humain ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2754969
  • Antigène Voir toutes PLA2R1 Anticorps
    PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))
    Épitope
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 395-530
    Reactivité
    • 17
    • 2
    Humain
    Hôte
    • 14
    • 3
    • 1
    Lapin
    Clonalité
    • 15
    • 3
    Polyclonal
    Conjugué
    • 12
    • 4
    • 1
    • 1
    Cet anticorp PLA2R1 est non-conjugé
    Application
    • 11
    • 10
    • 7
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Secretory phospholipase A2 receptor protein (395-530AA)
    Isotype
    IgG
    Top Product
    Discover our top product PLA2R1 Anticorps primaire
  • Indications d'application
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))
    Autre désignation
    PLA2R1 (PLA2R1 Produits)
    Synonymes
    anticorps Pla2-r, anticorps Pla2g1br, anticorps Pla2r, anticorps CLEC13C, anticorps PLA2-R, anticorps PLA2G1R, anticorps PLA2IR, anticorps PLA2R, anticorps phospholipase A2 receptor 1, anticorps PLA2R1, anticorps Pla2r1
    Sujet

    Background: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

    Aliases: 180 kDa secretory phospholipase A2 receptor antibody, C-type lectin domain family 13 member C antibody, CLEC13C antibody, M type receptor antibody, M-type receptor antibody, Phospholipase A2 receptor 1 antibody, PLA2 R antibody, PLA2-R antibody, PLA2G1R antibody, PLA2IR antibody, PLA2R antibody, PLA2R_HUMAN antibody, PLA2R1 antibody, Soluble PLA2-R antibody, Soluble PLA2R antibody, Soluble secretory phospholipase A2 receptor antibody

    UniProt
    Q13018
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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