anticorps pi8, anticorps cap2, anticorps CAP-2, anticorps CAP2, anticorps NK10, anticorps Spi8, anticorps ovalbumin, anticorps PI8, anticorps serpin family B member 8, anticorps serpin B8, anticorps serpin peptidase inhibitor, clade B (ovalbumin), member 8, anticorps serine (or cysteine) peptidase inhibitor, clade B, member 8, anticorps Serpinb8, anticorps SERPINB8, anticorps LOC607205, anticorps serpinb8, anticorps LOC100424017
Sujet
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8, SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]). Alias Symbols: CAP2, PI8 Protein Interaction Partner: SUMO2, LARS, UBC, CAP1, PRSS1, F10, F2, FURIN, BCL2, Protein Size: 374