CDKN2B anticorps (Middle Region)

N° du produit ABIN2774603

Détail du produit anti-CDKN2B anticorps

Antigène: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Porc, Chien, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDKN2B est non-conjugé

Application: Western Blotting (WB)

Séquence: REGFLDTLVV LHRAGARLDV RDAWGRLPVD LAEERGHRDV AGYLRTATGD

Homologie: Dog: 91%, Guinea Pig: 83%, Mouse: 83%, Pig: 100%, Rabbit: 91%, Rat: 83%

Attributs du produit: This is a rabbit polyclonal antibody against CDKN2B. It was validated on Western Blot using a cell lysate as a positive control.

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CDKN2B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 138 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CDKN2B

Antigène: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Autre désignation: CDKN2B (CDKN2B Produits)

Sujet: CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition.
Alias Symbols: P15, MTS2, TP15, CDK4I, INK4B, p15INK4b
Protein Interaction Partner: UBC, TRAF1, CDK6, CCDC33, NIF3L1, CDK4, PYCRL, RNF20, TGFB1I1, ISL1, APP, KIAA1377, CCDC90B, ARPC3, ZBTB17, IKBKAP, CDK8, MAGEA11, PIAS2,
Protein Size: 138

Poids moléculaire: 15 kDa

ID gène: 1030

NCBI Accession: NM_004936, NP_004927

UniProt: P42772

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases