RFWD2 anticorps (Middle Region)

N° du produit ABIN2775650

Détail du produit anti-RFWD2 anticorps

Antigène: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Cheval, Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RFWD2 est non-conjugé

Application: Western Blotting (WB)

Séquence: MSGLYSPVSE DSTVPQFEAP SPSHSSIIDS TEYSQPPGFS GTSQTKKQPW

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Rfwd2. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 733 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RFWD2

Antigène: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Autre désignation: Rfwd2 (RFWD2 Produits)

Synonymes: anticorps COP1, anticorps RNF200, anticorps AI316802, anticorps C80879, anticorps Cop1, anticorps RGD1304773, anticorps RFWD2, anticorps cop1, anticorps rnf200, anticorps zgc:163067, anticorps ring finger and WD repeat domain 2, anticorps ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, anticorps ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog, anticorps RFWD2, anticorps Rfwd2, anticorps rfwd2, anticorps rfwd2.L

Sujet: Rfwd2 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It is involved in JUN ubiquitination and degradation and directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Rfwd2 probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.
Alias Symbols: AI316802, C80879, Cop1
Protein Interaction Partner: CRY2, Reg1, Ptpn11, Fasn, Trib3, Trib2, Trib1,
Protein Size: 733

Poids moléculaire: 80 kDa

ID gène: 26374

NCBI Accession: NM_011931, NP_036061

UniProt: Q9R1A8

Pathways: Photoperiodism