VDAC1 anticorps (C-Term)

N° du produit ABIN2776153

Détail du produit anti-VDAC1 anticorps

Antigène: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Épitope: C-Term

Reactivité: Humain, Rat, Souris, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval, Mouton, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VDAC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: SAKVNNSSLI GLGYTQTLKP GIKLTLSALL DGKNVNAGGH KLGLGLEFQA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against VDAC1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human VDAC1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 283 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-VDAC1 (ABIN2776153)

Rousset, Nguyen, Grange, Morel, Lardy: "Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes." dans: PLoS ONE, Vol. 8, Issue 6, pp. e66478, (2013) (PubMed).

Arduíno, Esteves, Cortes, Silva, Patel, Grazina, Swerdlow, Oliveira, Cardoso: "Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic." dans: Human molecular genetics, Vol. 21, Issue 21, pp. 4680-702, (2012) (PubMed).

Chen, Martin, Maya-Mendoza, Tang, Lovri?, Sims, Jackson: "Reduced expression of lamin A/C results in modified cell signaling and metabolism coupled with changes in expression of structural proteins." dans: Journal of proteome research, Vol. 8, Issue 11, pp. 5196-211, (2009) (PubMed).

Détails sur VDAC1

Antigène: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Autre désignation: VDAC1 (VDAC1 Produits)

Synonymes: anticorps vdac1, anticorps VDAC1, anticorps 5076, anticorps ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1, anticorps ATVDAC1, anticorps T22N4.9, anticorps T22N4_9, anticorps voltage dependent anion channel 1, anticorps PORIN, anticorps VDAC-1, anticorps AL033343, anticorps Vdac5, anticorps fa13f11, anticorps wu:fa13f11, anticorps zgc:85830, anticorps voltage-dependent anion channel 1 S homeolog, anticorps voltage-dependent anion channel 1, anticorps voltage dependent anion channel 1, anticorps vdac1.S, anticorps vdac1, anticorps VDAC1, anticorps Vdac1

Sujet: The voltage-dependent anion-selective channel 1 (VDAC1) functions as a channel in membranous structures for the outer mitochondrial membrane, the cell membrane, endosomes, caveolae, the sarcoplasmatic reticulum, synaptosomes, and post-synaptic density fraction. A major function of VDAC1 in the plasma membrane is that of a NADH(-ferricyanide) reductase that may be involved in the maintenance of cellular redox homeostasis.
Alias Symbols: PORIN, VDAC-1
Protein Interaction Partner: UBC, KLHL40, SPRTN, MDM2, ADRB2, ASB14, ASB17, PARK2, BAG3, env, VCAM1, HK1, ATF2, FMNL1, TUBA1B, MDC1, CAV1, Htt, SFXN3, SUGP1, UBAP2, UFM1, ACAD9, MGAT4B, ACAA2, ZMPSTE24, VAPA, ALDH5A1, SF1, VDAC3, VDAC2, UBA52, TIAL1, FLOT2, CDK2, SIRT7, SUMO4, MAPK3,
Protein Size: 283

Poids moléculaire: 31 kDa

ID gène: 7416

NCBI Accession: NM_003374, NP_003365

UniProt: Q5FVE7