KCNJ1 anticorps (Middle Region)

N° du produit ABIN2776290

Détail du produit anti-KCNJ1 anticorps

Antigène: KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Cheval, Chien, Cobaye, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNJ1 est non-conjugé

Application: Western Blotting (WB)

Séquence: LRKSLLIGSH IYGKLLKTTV TPEGETIILD QININFVVDA GNENLFFISP

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against KCNJ1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human KCNJ1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 391 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KCNJ1 (ABIN2776290)

Tobin, Tomaszewski, Braund, Hajat, Raleigh, Palmer, Caulfield, Burton, Samani: "Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population." dans: Hypertension, Vol. 51, Issue 6, pp. 1658-64, (2008) (PubMed).

Détails sur KCNJ1

Antigène: KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))

Autre désignation: KCNJ1 (KCNJ1 Produits)

Synonymes: anticorps KIR1.1, anticorps ROMK, anticorps ROMK1, anticorps kir1.1, anticorps romk1, anticorps Kcnj, anticorps Kir1.1, anticorps Romk2, anticorps kcnj1, anticorps wu:fl37c05, anticorps zgc:63534, anticorps potassium voltage-gated channel subfamily J member 1, anticorps potassium voltage-gated channel subfamily J member 1 L homeolog, anticorps potassium inwardly-rectifying channel, subfamily J, member 1, anticorps potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1, anticorps KCNJ1, anticorps kcnj1.L, anticorps kcnj1, anticorps Kcnj1, anticorps kcnj1a.1

Sujet: KCNJ1 has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for KCNJ1.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: KIR1.1, ROMK, ROMK1
Protein Interaction Partner: SH3RF1, UBC, SLC9A3R2, SLC9A3R1, SGK1, GOLGA3, PRKCD, IL16, CFTR,
Protein Size: 391

Poids moléculaire: 45 kDa

ID gène: 3758

NCBI Accession: NM_000220, NP_000211

UniProt: P48048