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KCNQ2 anticorps (N-Term)

KCNQ2 Reactivité: Rat, Humain, Souris, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio) WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2776303
  • Antigène Voir toutes KCNQ2 Anticorps
    KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))
    Épitope
    • 16
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 30
    • 19
    • 14
    • 11
    • 10
    • 6
    • 6
    • 5
    • 5
    • 5
    • 1
    • 1
    Rat, Humain, Souris, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)
    Hôte
    • 34
    • 1
    Lapin
    Clonalité
    • 35
    Polyclonal
    Conjugué
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp KCNQ2 est non-conjugé
    Application
    • 18
    • 15
    • 13
    • 13
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    IDIMVLIASI AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%
    Attributs du produit
    This is a rabbit polyclonal antibody against KCNQ2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human KCNQ2
    Top Product
    Discover our top product KCNQ2 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 393 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))
    Autre désignation
    KCNQ2 (KCNQ2 Produits)
    Synonymes
    anticorps BFNC, anticorps BFNS1, anticorps EBN, anticorps EBN1, anticorps EIEE7, anticorps ENB1, anticorps HNSPC, anticorps KCNA11, anticorps KV7.2, anticorps KVEBN1, anticorps KQT2, anticorps Nmf134, anticorps mKQT2.3, anticorps mKQT2.4, anticorps zgc:171872, anticorps potassium voltage-gated channel subfamily Q member 2, anticorps potassium voltage-gated channel, subfamily Q, member 2, anticorps potassium voltage-gated channel subfamily KQT member 2, anticorps potassium voltage-gated channel, KQT-like subfamily, member 2a, anticorps KCNQ2, anticorps Kcnq2, anticorps LOC100537363, anticorps kcnq2a
    Sujet
    The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by KCNQ2 and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
    Alias Symbols: BFNC, EBN, EBN1, ENB1, HNSPC, KCNA11, KV7.2, KVEBN1, BFNS1, EIEE7
    Protein Interaction Partner: ARIH2, KCNQ3, PRKCA, CALM3, CALM1, CALM2, KCNQ1,
    Protein Size: 393
    Poids moléculaire
    44 kDa
    ID gène
    3785
    NCBI Accession
    NM_172109, NP_742107
    UniProt
    Q53Y30
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