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UPF3B anticorps (Middle Region)

UPF3B Reactivité: Humain, Souris, Rat, Chien, Lapin, Porc WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2776615
  • Antigène Voir toutes UPF3B Anticorps
    UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
    Épitope
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Chien, Lapin, Porc
    Hôte
    • 14
    Lapin
    Clonalité
    • 14
    Polyclonal
    Conjugué
    • 11
    • 1
    • 1
    • 1
    Cet anticorp UPF3B est non-conjugé
    Application
    • 9
    • 5
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Séquence
    KIDRIPERDK LKDEPKIKVH RFLLQAVNQK NLLKKPEKGD EKELDKREKA
    Homologie
    Dog: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against UPF3B. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human UPF3B
    Top Product
    Discover our top product UPF3B Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 483 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
    Autre désignation
    UPF3B (UPF3B Produits)
    Synonymes
    anticorps HUPF3B, anticorps MRXS14, anticorps RENT3B, anticorps UPF3X, anticorps 5730594O13Rik, anticorps AI317193, anticorps AW541158, anticorps RGD1560264, anticorps UPF3B, regulator of nonsense mediated mRNA decay, anticorps UPF3 regulator of nonsense transcripts homolog B (yeast), anticorps UPF3B, anticorps Upf3b
    Sujet
    UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
    Alias Symbols: HUPF3B, MRXS14, RENT3B, UPF3X
    Protein Interaction Partner: NCBP1, CIAO1, STAU1, UBC, UPF1, HECW2, RBM8A, UPF2, SMG1, EIF4A3, WIBG, WBP11, RNPS1, SART1, TOP2A, SNRPA1, NXF1, CAND1, COPS5, CUL5, USP21, EXOSC4, MCRS1, XRN1, TTC19, EIF6, UPF3B, HBB, UPF3A,
    Protein Size: 483
    Poids moléculaire
    58 kDa
    ID gène
    65109
    NCBI Accession
    NM_080632, NP_542199
    UniProt
    Q9BZI7
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