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ADAMTS4 anticorps (N-Term)

ADAMTS4 Reactivité: Humain, Souris, Rat, Cheval, Chien, Boeuf (Vache), Cobaye, Lapin WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2776877
  • Antigène Voir toutes ADAMTS4 Anticorps
    ADAMTS4 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4))
    Épitope
    • 15
    • 12
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 80
    • 47
    • 19
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Cheval, Chien, Boeuf (Vache), Cobaye, Lapin
    Hôte
    • 72
    • 10
    • 4
    Lapin
    Clonalité
    • 77
    • 9
    Polyclonal
    Conjugué
    • 40
    • 10
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ADAMTS4 est non-conjugé
    Application
    • 63
    • 29
    • 14
    • 13
    • 13
    • 13
    • 11
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    GVQVEGLTVQ YLGQAPELLG GAEPGTYLTG TINGDPESVA SLHWDGGALL
    Homologie
    Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against ADAMTS4. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human ADAMTS4
    Top Product
    Discover our top product ADAMTS4 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 339 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lee, Lee, Gil, Kim, Lee, Kim, Park: "Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases." dans: Archives of pathology & laboratory medicine, Vol. 138, Issue 5, pp. 643-50, (2014) (PubMed).

    Lee, Hwang, Park, Lee, Park, Kang, Lee, Kim, Park, Park: "Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina." dans: Journal of clinical pathology, Vol. 64, Issue 5, pp. 399-404, (2011) (PubMed).

    Boerboom, Lafond, Zheng, Lapointe, Mittaz, Boyer, Pritchard, DeMayo, Mort, Drolet, Richards: "Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla." dans: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 240, Issue 7, pp. 1806-14, (2011) (PubMed).

  • Antigène
    ADAMTS4 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4))
    Autre désignation
    ADAMTS4 (ADAMTS4 Produits)
    Synonymes
    anticorps 3830423K05, anticorps ADAM-TS4, anticorps ADAMTS-2, anticorps ADMP-1, anticorps mKIAA0688, anticorps ADAMTS-4, anticorps ADAMTS4, anticorps a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4, anticorps ADAM metallopeptidase with thrombospondin type 1 motif 4, anticorps ADAM metallopeptidase with thrombospondin type 1 motif, 4, anticorps Adamts4, anticorps ADAMTS4
    Sujet
    ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. ADAMTS4 lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
    Alias Symbols: ADAMTS-2, ADAMTS-4, ADMP-1, KIAA0688
    Protein Interaction Partner: YTHDC1, ZBTB16, ELAVL1, UBC, MT2A, SRPX2, ADAMTS4, BCAN, SERPINA1, ACAN, HP, FURIN, FN1, SERPINA3,
    Protein Size: 339
    Poids moléculaire
    37 kDa
    ID gène
    9507
    UniProt
    Q8NEK2
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