CYP2D6 anticorps (N-Term)
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- Antigène Voir toutes CYP2D6 Anticorps
- CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))
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Épitope
- N-Term
- Reactivité
- Humain, Souris, Rat, Mouton, Porc, Lapin, Chien, Cobaye, Cheval, Boeuf (Vache), Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CYP2D6 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE
- Homologie
- Cow: 91%, Dog: 79%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 100%, Sheep: 86%, Zebrafish: 92%
- Attributs du produit
- This is a rabbit polyclonal antibody against CYP2D6. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human CYP2D6
- Top Product
- Discover our top product CYP2D6 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 497 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))
- Autre désignation
- CYP2D6 (CYP2D6 Produits)
- Synonymes
- anticorps CPD6, anticorps CYP2D, anticorps CYP2D7AP, anticorps CYP2D7BP, anticorps CYP2D7P2, anticorps CYP2D8P2, anticorps CYP2DL1, anticorps CYPIID6, anticorps P450-DB1, anticorps P450C2D, anticorps P450DB1, anticorps CYP2D42, anticorps MGC64445, anticorps cyp2d2, anticorps cyp2d6-a, anticorps CYP2D6, anticorps cytochrome P450 family 2 subfamily D member 6, anticorps cytochrome P450, family 2, subfamily D, polypeptide 6, anticorps cytochrome 2D6, anticorps cytochrome P450 family 2 subfamily D member 6 S homeolog, anticorps cytochrome P450 2D6, anticorps cytochrome P450 2D6-like, anticorps CYP2D6, anticorps cyp2d6-b, anticorps cyp2d6.S, anticorps cyp2d6, anticorps LOC100988273
- Sujet
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CYP2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20 % of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug, sparteine and propafenone, both anti-arrythmic drugs, and amitryptiline, an anti-depressant.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20 % of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug, sparteine and propafenone, both anti-arrythmic drugs, and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population, certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: RP4-669P10.2, CPD6, CYP2D, CYP2D@, CYP2DL1, MGC120389, MGC120390, P450-DB1, P450C2D, CYPIID6, P450DB1, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2
Protein Interaction Partner: CYP2D6, CYP2C9, POR, CYB5A,
Protein Size: 497 - Poids moléculaire
- 55 kDa
- ID gène
- 1565
- NCBI Accession
- NM_000106, NP_000097
- UniProt
- P10635
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