SERPINB5 anticorps (Middle Region)

N° du produit ABIN2777125

Détail du produit anti-SERPINB5 anticorps

Antigène: SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 (SERPINB5))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Cobaye, Chien, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SERPINB5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: NSVNDQTKIL VVNAAYFVGK WMKKFPESET KECPFRLNKT DTKPVQMMNM

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 93%, Mouse: 86%, Rabbit: 86%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against SERPINB5. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SERPINB5

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 375 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SERPINB5 (ABIN2777125)

Mardin, Ntalos, Mees, Spieker, Senninger, Haier, Dhayat: "SERPINB5 Promoter Hypomethylation Differentiates Pancreatic Ductal Adenocarcinoma From Pancreatitis." dans: Pancreas, Vol. 45, Issue 5, pp. 743-7, (2016) (PubMed).

Hrabakova, Kollareddy, Tyleckova, Halada, Hajduch, Gadher, Kovarova: "Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy." dans: Journal of proteome research, Vol. 12, Issue 1, pp. 455-69, (2013) (PubMed).

Mardin, Petrov, Enns, Senninger, Haier, Mees: "SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma." dans: BMC cancer, Vol. 10, pp. 549, (2010) (PubMed).

Détails sur SERPINB5

Antigène: SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 (SERPINB5))

Autre désignation: SERPINB5 (SERPINB5 Produits)

Synonymes: anticorps 1110036M19Rik, anticorps AI462524, anticorps AI646751, anticorps Maspin, anticorps PI-5, anticorps Spi7, anticorps ovalbumin, anticorps PI5, anticorps maspin, anticorps Pi5, anticorps serine (or cysteine) peptidase inhibitor, clade B, member 5, anticorps serpin family B member 5, anticorps serpin peptidase inhibitor, clade B (ovalbumin), member 5 S homeolog, anticorps Serpinb5, anticorps SERPINB5, anticorps serpinb5.S

Sujet: As a tumor suppressor, it blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Alias Symbols: PI5, maspin
Protein Interaction Partner: SUMO2, WWOX, FBXO32, KHDRBS3, ISG15, UBC, Cdk1, UCHL5, HDAC1,
Protein Size: 375

Poids moléculaire: 41 kDa

ID gène: 5268

NCBI Accession: NM_002639, NP_002630

UniProt: P36952

Pathways: Signalisation p53