Metabotropic Glutamate Receptor 6 anticorps (Middle Region)

N° du produit ABIN2777489

Détail du produit anti-Metabotropic Glutamate Receptor 6 anticorps

Antigène: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 6 est non-conjugé

Application: Western Blotting (WB)

Séquence: EFWEENFNCK LTSSGTQSDD STRKCTGEER IGRDSTYEQE GKVQFVIDAV

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 87%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 87%, Rat: 93%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against GRM6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human GRM6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 877 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Metabotropic Glutamate Receptor 6

Antigène: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Autre désignation: GRM6 (GRM6 Produits)

Synonymes: anticorps mGluR6, anticorps CSNB1B, anticorps GPRC1F, anticorps MGLUR6, anticorps mGlu6, anticorps GRM6, anticorps BC021919, anticorps Gm3, anticorps Gprc1f, anticorps nerg1, anticorps nob2, anticorps nob3, anticorps nob4, anticorps si:dkey-52h10.3, anticorps cb496, anticorps grma, anticorps zK13A21.16, anticorps zgc:158329, anticorps glutamate metabotropic receptor 6, anticorps glutamate receptor, metabotropic 6, anticorps glutamate receptor, metabotropic 6a, anticorps glutamate receptor, metabotropic 6b, anticorps Grm6, anticorps GRM6, anticorps grm6a, anticorps grm6b

Sujet: GRM6 is the receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Alias Symbols: CSNB1B, DKFZp686H1993, GPRC1F, MGLUR6, mGlu6
Protein Interaction Partner: GNAO1,
Protein Size: 877

Poids moléculaire: 95 kDa

ID gène: 2916

NCBI Accession: NM_000843, NP_000834

UniProt: O15303