PSMC3 anticorps (Middle Region)
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- Antigène Voir toutes PSMC3 Anticorps
- PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Boeuf (Vache), Lapin, Cheval, Cobaye
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PSMC3 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- TKRFDSEKAG DREVQRTMLE LLNQLDGFQP NTQVKVIAAT NRVDILD
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
- Attributs du produit
- This is a rabbit polyclonal antibody against PSMC3. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human PSMC3
- Top Product
- Discover our top product PSMC3 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 439 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor." dans: International journal of cancer. Journal international du cancer, Vol. 111, Issue 3, pp. 338-47, (2004) (PubMed).
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Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor." dans: International journal of cancer. Journal international du cancer, Vol. 111, Issue 3, pp. 338-47, (2004) (PubMed).
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- Antigène
- PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))
- Autre désignation
- PSMC3 (PSMC3 Produits)
- Synonymes
- anticorps TBP1, anticorps TBP-1, anticorps wu:fb39a02, anticorps zgc:86713, anticorps psmc3, anticorps MGC89608, anticorps PSMC3, anticorps NV15940, anticorps 23.m06430, anticorps DDBDRAFT_0186002, anticorps DDBDRAFT_0232967, anticorps DDB_0186002, anticorps DDB_0232967, anticorps psmc3-b, anticorps tbp10, anticorps psmc3-a, anticorps proteasome 26S subunit, ATPase 3, anticorps proteasome (prosome, macropain) 26S subunit, ATPase 3, anticorps 26S protease regulatory subunit 6A, anticorps 26S protease regulatory subunit 6a, anticorps 26S protease regulatory subunit 6A-B, anticorps 26S protease regulatory subunit 6A, putative, anticorps proteasome 26S subunit, ATPase 3 S homeolog, anticorps nth-like DNA glycosylase 1 S homeolog, anticorps PSMC3, anticorps Psmc3, anticorps HCAG_00069, anticorps GL50803_4365, anticorps EDI_316920, anticorps CpipJ_CPIJ006888, anticorps CpipJ_CPIJ006889, anticorps CpipJ_CPIJ010864, anticorps prs6a, anticorps psmc3, anticorps LOC100115023, anticorps BBOV_IV004580, anticorps CGB_M2140W, anticorps psmC3, anticorps LOC100637883, anticorps psmc3.S, anticorps nthl1.S
- Sujet
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PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9
Alias Symbols: TBP1
Protein Interaction Partner: AMOTL2, UBC, PSMD9, PSMC6, PSMC3, KDM1A, HUWE1, SUMO2, PSMD14, MDM2, ASB11, UCHL5, PSMD3, PSMD2, PSMD1, PSMC2, PSMC1, ADRM1, JKAMP, FBXO6, PARK2, BAG3, GADD45A, NOS2, MYC, PSMD13, PSMC4, PSMA8, UBFD1, ECD, STIP1, RANBP9, PSMD6, ZFYVE16, USP14, RUVBL1, PSM
Protein Size: 439 - Poids moléculaire
- 45 kDa
- ID gène
- 5702
- NCBI Accession
- NM_002804, NP_002795
- UniProt
- Q6IBS1
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
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