MMP 9 anticorps (N-Term)

N° du produit ABIN2777743

Détail du produit anti-MMP 9 anticorps

Antigène: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Épitope: N-Term

Reactivité: Humain, Rat, Souris, Lapin, Boeuf (Vache), Chien, Cheval, Poisson zèbre (Danio rerio), Cobaye, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP 9 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: VAEHGDGYPF DGKDGLLAHA FPPGPGIQGD AHFDDDELWS LGKGVVVPTR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MMP9. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MMP9

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 707 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-MMP 9 (ABIN2777743)

Puttabyatappa, Irwin, Martin, Mesquitta, Veiga-Lopez, Padmanabhan: "Developmental Programming: Gestational Exposure to Excess Testosterone Alters Expression of Ovarian Matrix Metalloproteases and Their Target Proteins" dans: Reproductive sciences (Thousand Oaks, Calif.), pp. 1933719117697130, (2017) (PubMed).

Strilakou, Perelas, Lazaris, Papavdi, Karkalousos, Giannopoulou, Kriebardis, Panayiotides, Liapi: "Immunohistochemical determination of the extracellular matrix modulation in a rat model of choline-deprived myocardium: the effects of carnitine." dans: Fundamental & clinical pharmacology, Vol. 30, Issue 1, pp. 47-57, (2016) (PubMed).

Zhang, Jiang, Zuo: "Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor κB." dans: Neuroscience, Vol. 261, pp. 1-10, (2014) (PubMed).

Li, Tan, Zhang, Han, Di, Xiao, Cheng, Gao, Liu: "DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression depending on Notch signaling." dans: PLoS ONE, Vol. 9, Issue 3, pp. e91509, (2014) (PubMed).

Deng, Zhang, Feng, Xiong, Zuo: "Critical role of matrix metalloprotease-9 in chronic high fat diet-induced cerebral vascular remodelling and increase of ischaemic brain injury in mice†." dans: Cardiovascular research, Vol. 103, Issue 4, pp. 473-84, (2014) (PubMed).

Gotschy, Bauer, Schrodt, Lykowsky, Ye, Rommel, Jakob, Bauer, Herold: "Local arterial stiffening assessed by MRI precedes atherosclerotic plaque formation." dans: Circulation. Cardiovascular imaging, Vol. 6, Issue 6, pp. 916-23, (2013) (PubMed).

Détails sur MMP 9

Antigène: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Autre désignation: MMP9 (MMP9 Produits)

Synonymes: anticorps CLG4B, anticorps GELB, anticorps MANDP2, anticorps MMP-9, anticorps AW743869, anticorps B/MMP9, anticorps Clg4b, anticorps pro-MMP-9, anticorps mmp-9, anticorps fgMMP-9, anticorps mmp9, anticorps ZFMMP-9, anticorps wu:fb02g06, anticorps wu:fb07b05, anticorps wu:fi98c09, anticorps wu:fj05a08, anticorps zgc:64165, anticorps clg4b, anticorps gelb, anticorps mandp2, anticorps matrix metallopeptidase 9, anticorps collagenase, anticorps matrix metalloproteinase 9, anticorps matrix metallopeptidase 9 S homeolog, anticorps MMP9, anticorps RB3913, anticorps BPSS0666, anticorps Sbal_3732, anticorps Bcer98_0486, anticorps Shew185_0630, anticorps Shal_3056, anticorps Sbal195_0657, anticorps Lbys_3550, anticorps Palpr_2084, anticorps Mmp9, anticorps mmp9, anticorps mmp9.S

Sujet: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Alias Symbols: GELB, CLG4B, MMP-9, MANDP2
Protein Interaction Partner: CXCL5, PZP, MMP26, RECK, KISS1, PRSS2, EPHB2, BTC, LCN2, COL4A6, COL4A5, TIMP3, THBS2, THBS1, MMP10, MMP7, PLG, CXCL1, TFPI, CXCL8, FN1, MMP9, COL1A2, COL1A1, COL4A4, COL4A1, COL4A2, COL4A3, HAPLN1, CD44, AREG, TGFB1, CXCL6,
Protein Size: 707

Poids moléculaire: 78 kDa

ID gène: 4318

NCBI Accession: NM_004994, NP_004985

UniProt: P14780

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events