PCSK1 anticorps (Middle Region)

N° du produit ABIN2778153

Détail du produit anti-PCSK1 anticorps

Antigène: PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))

Épitope: Middle Region

Reactivité: Rat, Humain, Souris, Cobaye, Cheval, Lapin, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCSK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: QSPKKSPSAK LNIPYENFYE ALEKLNKPSQ LKDSEDSLYN DYVDVFYNTK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PCSK1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PCSK1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 753 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PCSK1

Antigène: PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))

Autre désignation: PCSK1 (PCSK1 Produits)

Synonymes: anticorps BMIQ12, anticorps NEC1, anticorps PC1, anticorps PC3, anticorps SPC3, anticorps Nec-1, anticorps Nec1, anticorps Phpp-1, anticorps BDP, anticorps PC1/3, anticorps proprotein convertase subtilisin/kexin type 1, anticorps prohormone convertase 1, anticorps PCSK1, anticorps Pcsk1, anticorps pcsk1, anticorps PC1B

Sujet: PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: NEC1, PC1, PC3, SPC3, BMIQ12
Protein Interaction Partner: env, AFF1, PCSK1N, REN, PMCH, IAPP, PTK2, CTNNB1,
Protein Size: 753

Poids moléculaire: 71 kDa

ID gène: 5122

NCBI Accession: NM_000439, NP_000430

UniProt: P29120

Pathways: Peptide Hormone Metabolism