EYA4 anticorps (N-Term)

N° du produit ABIN2778551

Détail du produit anti-EYA4 anticorps

Antigène: EYA4 (Eyes Absent Homolog 4 (EYA4))

Épitope: N-Term

Reactivité: Humain, Souris, Lapin, Cobaye, Chien, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EYA4 est non-conjugé

Application: Western Blotting (WB)

Séquence: MEDTQDLNEQ SVKKTCPEAD VSEPQNSRSM EMQDLASPHA LVGGSDTPGS

Homologie: Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against Eya4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Eya4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 616 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur EYA4

Antigène: EYA4 (Eyes Absent Homolog 4 (EYA4))

Autre désignation: Eya4 (EYA4 Produits)

Synonymes: anticorps B130023L16Rik, anticorps CMD1J, anticorps DFNA10, anticorps EYA transcriptional coactivator and phosphatase 4, anticorps Eya4, anticorps EYA4

Sujet: Eya4 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Eya4 promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. It may be involved in development of the eye.
Alias Symbols: B130023L16Rik
Protein Interaction Partner: Six1, Six2, Eya4,
Protein Size: 616

Poids moléculaire: 67 kDa

ID gène: 14051

NCBI Accession: NM_010167, NP_034297

UniProt: Q9Z191

Pathways: Sensory Perception of Sound