Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4) (Middle Region) anticorps

Détails pour le produit réf. ABIN2778873
Antigène
  • cb12
  • sb:cb12
  • PABP
  • ePAB
  • ePABP
  • APP-1
  • APP1
  • PABP4
  • iPABP
  • polyadenylate-binding protein 4
  • poly(A) binding protein, cytoplasmic 4
  • poly(A) binding protein, cytoplasmic 4 (inducible form)
  • poly(A) binding protein cytoplasmic 4 L homeolog
  • poly(A) binding protein cytoplasmic 4
  • Bm1_06880
  • Pabpc4
  • pabpc4
  • pabpc4.L
  • PABPC4
Épitope
Middle Region
9
9
7
7
4
2
2
2
1
1
1
1
1
Reactivité
Boeuf (Vache), Chien, Cobaye, Cheval, Humain, Souris, Lapin, Rat (Rattus)
57
22
22
7
5
5
4
3
2
2
1
1
Hôte
Lapin
57
Clonalité
Polyclonal
Conjugué
Inconjugué
3
2
2
2
2
2
1
1
1
1
1
1
Application
Western Blotting (WB)
49
23
22
9
5
4
2
1
1
Options
Immunogène The immunogen is a synthetic peptide directed towards the middle region of human PABPC4
Blocking Peptide Blocking peptide for this product available: ABIN981296
Séquence RPNPRWQQGG RPQGFQGMPS AIRQSGPRPT LRHLAPTGSE CPDRLAMDFG
Homologie Cow: 93%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%
Attributs du produit This is a rabbit polyclonal antibody against PABPC4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Antigène
Autre désignation PABPC4 (PABPC4 Antibody Extrait)
Sujet Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: APP-1, APP1, PABP4, iPABP
Protein Interaction Partner: FBXW11, UBC, IVNS1ABP, STAU1, RPA3, RPA2, RPA1, WWOX, SUZ12, RNF2, EZH2, BMI1, NCAPD2, DDX5, TARDBP, SRPK2, CLK3, YWHAQ, UBD, EIF2AK2, PAN2, UBL4A, SMAD9, ITGA4, IL7R, IFIT3, IFIT1, IFIT2, FN1, IGBP1, NUBP2, CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A,
Protein Size: 644
Poids moléculaire 71 kDa
ID gène 8761
NCBI Accession NM_003819, NP_003810
UniProt Q13310
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 644 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images (Fournisseur)
Western Blotting (WB) image for anti-Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4) (Middle Region) antibody (ABIN2778873) WB Suggested Anti-PABPC4 Antibody Titration: 0.2-1 ug/ml Positive Control: HepG2 c...
Produit citée dans: Liu, Yin, Wang, Ju, Chen, Qiu, Li, Peng, Lu: "Cytoplasmic poly(A) binding protein 4 is highly expressed in human colorectal cancer and correlates with better prognosis." dans: Journal of genetics and genomics = Yi chuan xue bao, Vol. 39, Issue 8, pp. 369-74, 2012 (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." dans: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).

Avez-vous cherché autre chose?