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TAB2 anticorps (N-Term)

TAB2 Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2779619
  • Antigène Voir toutes TAB2 Anticorps
    TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
    Épitope
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    N-Term
    Reactivité
    • 17
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin
    Hôte
    • 16
    • 3
    Lapin
    Clonalité
    • 18
    • 1
    Polyclonal
    Conjugué
    • 19
    Cet anticorp TAB2 est non-conjugé
    Application
    • 14
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    QKFPEVPEVV VSRCMLQNNN NLDACCAVLS QESTRYLYGE GDLNFSDDSG
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against MAP3K7IP2. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human MAP3K7IP2
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 693 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Thienpont, Zhang, Postma, Breckpot, Tranchevent, Van Loo, Møllgård, Tommerup, Bache, Tümer, van Engelen, Menten, Mortier, Waggoner, Gewillig, Moreau, Devriendt, Larsen: "Haploinsufficiency of TAB2 causes congenital heart defects in humans." dans: American journal of human genetics, Vol. 86, Issue 6, pp. 839-49, (2010) (PubMed).

  • Antigène
    TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
    Autre désignation
    MAP3K7IP2 (TAB2 Produits)
    Synonymes
    anticorps CHTD2, anticorps MAP3K7IP2, anticorps 1110030N06Rik, anticorps A530078N03Rik, anticorps Map3k7ip2, anticorps mKIAA0733, anticorps map3k7ip2, anticorps zgc:77446, anticorps TGF-beta activated kinase 1/MAP3K7 binding protein 2, anticorps TAB2, anticorps Tab2, anticorps tab2
    Sujet
    MAP3K7IP2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of NF.:B and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serving as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF.:B (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
    Alias Symbols: CHTD2, MAP3K7IP2
    Protein Interaction Partner: UBC, PIAS3, UBE2I, TRAF6, SUMO2, IRAK1, MAP3K7, TRIM38, SIK1, SIK3, TRIM22, NPM1, CST9L, SLC19A3, env, TAB1, NUMBL, IKBKG, FOSL1, ZBTB16, YWHAZ, VIM, TGM2, PPP2CB, IKBKB, GTF2I, FN1, HSP90AA1, BST2, MALT1, WDR34, APP, ESR1, MAP3K8, AR, TRIM5, TBL1XR1, MBD
    Protein Size: 693
    Poids moléculaire
    76 kDa
    ID gène
    23118
    NCBI Accession
    NM_015093, NP_055908
    UniProt
    Q9NYJ8
    Pathways
    TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
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