RUNX1 anticorps (N-Term)

N° du produit ABIN2780299

Détail du produit anti-RUNX1 anticorps

Antigène: RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RUNX1 est non-conjugé

Application: Western Blotting (WB)

Séquence: KMSEALPLGA PDGGPALASK LRSGDRSMVE VLADHPGELV RTDSPNFLCS

Homologie: Cow: 79%, Dog: 79%, Guinea Pig: 79%, Human: 79%, Mouse: 100%, Rabbit: 79%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against Runx1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of MOUSE Runx1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RUNX1

Antigène: RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))

Autre désignation: Runx1 (RUNX1 Produits)

Synonymes: anticorps RUNX1, anticorps runx1, anticorps AI462102, anticorps AML1, anticorps Cbfa2, anticorps Pebp2a2, anticorps Pebpa2b, anticorps AML1-EVI-1, anticorps AMLCR1, anticorps CBFA2, anticorps EVI-1, anticorps PEBP2aB, anticorps runxa, anticorps Runx-1, anticorps XAML, anticorps Xaml1, anticorps aml, anticorps aml-1, anticorps aml1, anticorps aml1-evi-1, anticorps amlcr1, anticorps cbfa2, anticorps evi-1, anticorps pebp2ab, anticorps Aml1, anticorps uncharacterized LOC473981, anticorps runt-related transcription factor, anticorps runt related transcription factor 1, anticorps runt-related transcription factor 1, anticorps runt related transcription factor 1 L homeolog, anticorps LOC473981, anticorps runt, anticorps Runx1, anticorps RUNX1, anticorps runx1, anticorps runx1.L

Sujet: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Runx1 is essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Runx1 acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. It inhibits KAT6B-dependent transcriptional activation .
Alias Symbols: AI462102, AML1, Cbfa2, Pebp2a2, Pebpa2b
Protein Interaction Partner: Kat6a, Ubc, Cbfb, Foxp3, Rbbp4, Gata1, Fli1, Phc1, Cdk6, Cbx3, Bmi1, Pml, Mbd3, Smad2, Prmt1, Hdac2, Hcfc1, Gata2, Hdac1, Wdr5, Mta1, Smarcd1, Pcgf5, Smarcc2, Pold3, Smarce1, Set, Mta2, Ash2l, Tal1, Smarcc1, Smarcb1, Smarca4, Sin3a, Rnf2, Ring1, Cbfa2t3,
Protein Size: 387

Poids moléculaire: 42 kDa

ID gène: 12394

NCBI Accession: NM_009821, NP_033951