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CBFA2T2 anticorps (N-Term)

CBFA2T2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2780644
  • Antigène Voir toutes CBFA2T2 Anticorps
    CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
    Épitope
    • 15
    • 9
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 56
    • 10
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 49
    • 6
    • 3
    • 1
    Lapin
    Clonalité
    • 54
    • 5
    Polyclonal
    Conjugué
    • 35
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CBFA2T2 est non-conjugé
    Application
    • 57
    • 22
    • 13
    • 13
    • 9
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    AKESGISLKE IQVLARQWKV GPEKRVPAMP GSPVEVKIQS RSSPPTMPPL
    Homologie
    Human: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against CBFA2T2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human CBFA2T2
    Top Product
    Discover our top product CBFA2T2 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 604 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
    Autre désignation
    CBFA2T2 (CBFA2T2 Produits)
    Synonymes
    anticorps MTGR1, anticorps A430091M07, anticorps C330013D05Rik, anticorps Cbfa2t2h, anticorps EHT, anticorps ZMYND3, anticorps p85, anticorps XETOR, anticorps cbfa2t2-a, anticorps CBFA2/RUNX1 translocation partner 2, anticorps core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human), anticorps CBFA2/RUNX1 translocation partner 2 L homeolog, anticorps Cbfa2t2, anticorps CBFA2T2, anticorps cbfa2t2.L
    Sujet
    In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. CBFA2T2 binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
    Alias Symbols: DKFZp313F2116, EHT, MTGR1, ZMYND3, p85
    Protein Interaction Partner: PRDM14, PDP1, CBFA2T2, TCP1, MDFI, RUNX1T1, LBP, APP, ATXN1L, ATN1, RERE, RUNX1, SIN3A, NCOR1, HDAC3, FBXL19, TAL2, NEUROG1, ID3, GTF2E1, WDYHV1, CBFA2T3, NCOR2, CBFB, TAL1,
    Protein Size: 604
    Poids moléculaire
    67 kDa
    ID gène
    9139
    NCBI Accession
    NM_005093, NP_005084
    UniProt
    O43439
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