NR1D2 anticorps (C-Term)

N° du produit ABIN2780650

Détail du produit anti-NR1D2 anticorps

Antigène: NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))

Épitope: C-Term

Reactivité: Humain, Rat, Souris, Lapin, Boeuf (Vache), Chien, Cheval, Cobaye, Poisson zèbre (Danio rerio), Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR1D2 est non-conjugé

Application: Western Blotting (WB)

Séquence: ETLIRALRTL IMKNHPNEAS IFTKLLLKLP DLRSLNNMHS EELLAFKVHP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 92%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against NR1D2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human NR1D2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 579 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NR1D2

Antigène: NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))

Autre désignation: NR1D2 (NR1D2 Produits)

Synonymes: anticorps BD73, anticorps EAR-1R, anticorps RVR, anticorps HZF-2, anticorps Rev-erb, anticorps REV-ERBB, anticorps NR1D2, anticorps rvr, anticorps bd73, anticorps hzf2, anticorps ear-1r, anticorps hs.37288, anticorps NR1D2-A, anticorps Reverbbeta-A, anticorps reverbb1, anticorps reverbb, anticorps reverbb2, anticorps zgc:92019, anticorps nuclear receptor subfamily 1 group D member 2, anticorps nuclear receptor subfamily 1, group D, member 2, anticorps nuclear receptor subfamily 1, group D, member 2a, anticorps nuclear receptor subfamily 1, group D, member 2b, anticorps NR1D2, anticorps Nr1d2, anticorps nr1d2, anticorps nr1d2a, anticorps nr1d2b

Sujet: NR1D2 can interact with NCOA5 coactivator, leading to a strong increase of transcription of target genes. NR1D2 also binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3' and acts as a potent competitive transcriptional silencer and negative regulator of RORalpha mediated trans-activation. NR1D2 may play different roles in metabolism, inflammation, and circadian cycling in the organ-specific manner in homeostasis.
Alias Symbols: RVR, BD73, EAR-1R
Protein Interaction Partner: MID2, RBPMS, TRIM27, NOTCH2NL, KRTAP10-9, KRT40, KRTAP4-2, PRMT6, SKP1, UBC, SIN3B, KAT5, NCOR1, TAF9, TAF6, HDAC1, GTF2B, NCOA5, UBE2I, CUL1, NR1D1, RGN,
Protein Size: 579

Poids moléculaire: 65 kDa

ID gène: 9975

NCBI Accession: NM_005126, NP_005117

UniProt: Q14995

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway